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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Light chain proximal tubulopathy (LCPT) is a rare form of myeloma-related kidney disease characterized by cytoplasmic inclusions of monoclonal light chains within proximal tubular cells. LCPT frequently presents with Fanconi syndrome, whereas nephrotic-range proteinuria is rarely observed. Here, we report a case of LCPT associated with concomitant Fanconi and nephrotic syndromes in a patient with multiple myeloma.
A 73-year-old woman with systemic sclerosis was found to have progressive proteinuria without an increase in serum creatinine levels (1.1–1.2 mg/dL). Her proteinuria and hypoalbuminemia gradually worsened, eventually leading to the development of nephrotic syndrome. Laboratory findings showed glycosuria, elevated urinary β₂MG and NAG levels, hypokalemia, hypophosphatemia, and hypouricemia, consistent with Fanconi syndrome. She also had anemia with rouleaux formation, elevated serum IgG (2182 mg/dL), and monoclonal IgG with κ light chains on serum immunoelectrophoresis. Bone marrow biopsy showed that 12.6% plasma cells, leading to the diagnosis of multiple myeloma. Kidney biopsy demonstrated swollen proximal tubules with κ light chain-restricted cytoplasmic inclusions. Electron microscopy revealed phagolysosomes containing electron-dense deposits in the cytoplasm of proximal tubular cells, confirming the diagnosis of LCPT. Bortezomib and dexamethasone therapy was initiated, followed by daratumumab-based regimens. Proteinuria gradually decreased from 8.2 to 2.2 g/gCr over two years, while renal function remained stable.
This case suggests that LCPT can present with nephrotic-range proteinuria, presumably due to a combination of light chain overflow and impaired tubular reabsorption, even in the absence of glomerular involvement.
This abstract includes content previously presented at “The Japanese Society of Internal Medicine, Koto-Hajime 2025 (Osaka, Japan)”. Re-submission to WCN 2026 is permitted by the organizers of the original meeting.
