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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Hepatorenal cross-talk is well established in hepatorenal syndrome (HRS); however, the structural–functional interrelationship between the kidney and liver in patients with IgA nephropathy (IgAN) coexisting with chronic liver disease (CLD) has not been quantitatively delineated. This study aimed to characterize the bidirectional kidney–liver interactions in this population and determine whether their correlation pattern mirrors HRS-like physiology.
A retrospective study was conducted in 60 patients with biopsy-proven IgAN and concomitant CLD. Renal parameters—serum creatinine, estimated glomerular filtration rate (eGFR), and urine protein–creatinine ratio (UPCR)—were evaluated alongside liver disease markers including albumin, total bilirubin, sodium, international normalized ratio (INR), Model for End-Stage Liver Disease–Sodium (MELD-Na) score, and Child–Pugh grade. Correlations were assessed by Pearson or Spearman methods, and linear regression models quantified predictive relationships between liver and kidney indices.
Strong correlations were identified between kidney dysfunction and liver disease severity. Serum creatinine demonstrated a strong positive correlation with MELD-Na score (r=0.738, p<0.001), with the regression equation: Creatinine = -0.105 + 0.150 × MELD_Na (R²=0.545). eGFR showed a strong negative correlation with MELD-Na (r=-0.668, p<0.001), with regression: eGFR = 85.5 - 2.63 × MELD_Na (R²=0.446). UPCR negatively correlated with serum sodium (r=-0.286, p=0.033). Subgroup analysis revealed significantly higher MELD-Na scores (p=0.007), INR (p=0.012), and lower serum sodium (p=0.009) and albumin (p<0.001) in Child-Pugh Grade B versus Grade A patients.
Significant bidirectional kidney-liver interactions exist in patients with concurrent IgA nephropathy and chronic liver disease. The MELD-Na score emerges as the strongest predictor of kidney dysfunction severity, explaining 54.5% of creatinine variance and 44.6% of eGFR variance. These findings support comprehensive assessment of both organ systems in patients with hepatic IgAN and highlight the importance of MELD-Na scoring for risk stratification.
