Shock Index Trajectories and Their Association with Renal Recovery and Mortality in AKI Patients Undergoing CRRT: A Multicenter Cohort Study

 

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Shock Index Trajectories and Their Association with Renal Recovery and Mortality in AKI Patients Undergoing CRRT: A Multicenter Cohort Study

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Kipyo
Kim
Jihyun Baek spreesh7@chamc.co.kr Bundang CHA Medical Center Nephrology Seongnam-si Korea (Republic of) -
Kipyo Kim polarbee1001@chamc.co.kr Bundang CHA Medical Center Nephrology Seongnam-si Korea (Republic of) *
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Acute kidney injury poses a challenge to the management of critically ill patients, contributing to high mortality and morbidity. Many survivors of dialysis-requiring AKI (AKI-D) experience persistent kidney failure even after ICU discharge. However, no reliable marker for predicting kidney recovery has been established. We evaluated the associations between shock index (SI) trajectory and kidney recovery and mortality in AKI-D patients.

We retrospectively enrolled AKI-D patients who received continuous renal replacement therapy (CRRT) in the intensive care units of two tertiary care hospitals in Korea between January 2010 and December 2023. The primary endpoints were in-hospital death and RRT dependence at discharge. The SI, calculated as heart rate divided by systolic blood pressure, was obtained from 24 hours before to 48 hours after CRRT initiation. Its temporal trajectory and slope were also analyzed.

Among a total of 2,731 patients, 1,515 died, while among AKI-D survivors, 189 remained RRT-dependent and 1,027 showed renal recovery. Patients in the death group were older and had higher APACHE II and SOFA scores. Patients in the renal recovery group were younger and exhibited higher infection-related markers compared to the non-recovery group. The renal recovery group showed a decreasing trend in SI following CRRT initiation, whereas the death group maintained persistently high SI values. The non-recovery group demonstrated relatively lower SI levels during both the pre- and post-CRRT periods. In the Fine–Gray subdistribution hazard model considering death as a competing risk, a steeper negative slope of SI (measured from 24 hours before to 48 hours after CRRT initiation) was associated with a higher risk of RRT dependence (sHR 1.41, 95% CI 1.29–1.54). In logistic regression excluding deaths, the odds ratio (OR) for kidney non-recovery was 1.72 (95% CI 1.25–2.38). 1.25–2.38).

 Shock Index trajectories

These findings suggest that the trajectory of the Shock Index in AKI-D patients provides valuable prognostic information regarding both mortality and renal recovery, and may serve as a useful predictive marker for clinical outcomes in this population.

Kewords