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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Acute kidney injury (AKI) occurs in 30–60% of critically ill patients and is linked to higher rates of morbidity and mortality. The estimation of renal function using creatinine-based estimated glomerular filtration rate (eGFR-Cr) using the CKD-EPI equation is often limited by confounding factors. To enhance accuracy in assessing unstable renal function, alternative derivation such as kinetic eGFR (kGFR) and the combined use of serum creatinine (SCr) and serum cystatin C (SCys) have been used. This study aims to compare the predictive value of eGFR-Cr, kGFR, and creatinine–cystatin C-based estimated GFR (eGFR-CrCys) in predicting renal recovery among critically ill adult patients with AKI in a single tertiary center.
This is a retrospective cohort study that analyzed data from adult patients diagnosed with AKI within 24 hours of admission to a critical care unit between January 2020 and December 2024. eGFR-Cr, kGFR, and eGFR-CrCys were derived using SCr and SCys obtained within 48 to 72 hours of AKI diagnosis. Renal recovery was defined as improvement in serum creatinine levels without the need for renal replacement therapy (RRT) after 7 days of AKI diagnosis. Major adverse kidney events (MAKE) included all-cause in-hospital mortality, initiation of RRT, or persistent renal dysfunction at discharge.
Over a 5-year period, 351 critically ill adults with AKI identified within 24 hours of admission were included. Renal recovery occurred in 58.4% of patients and major adverse kidney events were observed in 67.2% of patients, including 47.0% all-cause mortality, 23.1% requiring renal replacement therapy, and 54.1% developing persistent renal dysfunction. Patients who recovered kidney function had a significant difference in requirement of vasopressor use and RRT compared to those who did not recover. Of the predictive measures evaluated, eGFR-CrCys showed the best discrimination for renal recovery (AUC-ROC 0.809), with 88.3% sensitivity, 61.6% specificity, and 77.2% diagnostic accuracy, outperforming eGFR-Cr (AUC-ROC 0.750) and kGFR (AUC-ROC 0.710).
MAKE morbidity was observed in the majority of critically ill patients with AKI in this study. Among the evaluated measures, eGFR-CrCys demonstrated good discriminative ability in predicting renal recovery during the early phase of AKI, compared to eGFR-Cr and kGFR, which showed only fair discriminative performance. If validated in larger prospective studies, these findings may have important implications for the clinical management of AKI in critically ill patients.
