PROGNOSTIC VALUE OF CREATININE ON ADMISSION OF INTENSIVE CARE PATIENTS: A SINGLE-CENTER COHORT STUDY.

 

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https://storage.unitedwebnetwork.com/files/1099/663d2210e0bbb3be6f6cd2315ba1e2cc.pdf
PROGNOSTIC VALUE OF CREATININE ON ADMISSION OF INTENSIVE CARE PATIENTS: A SINGLE-CENTER COHORT STUDY.

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Nathan
Lubama
Jules Kuzeye juleskuzeye@gmail.com specialized clinics in kinshasa nephrology kinshasa Democratic Republic of Congo -
Francis Awoso fmangonzi@gmail.com specialized clinics in kinshasa nephrology kinshasa Democratic Republic of Congo -
James Kalunga wierwillejames@gmail.com specialized clinics in kinshasa nephrology kinshasa Democratic Republic of Congo -
Pitchou Kengibe pkengibe@gmail.com Kinshasa University Hospital nephrology kinshasa Democratic Republic of Congo -
Tresor Mvunzi tresormvunzi@gmail.com Kinshasa University Hospital nephrology kinshasa Democratic Republic of Congo -
Yannick Engole yannickengole@yahoo.fr Kinshasa University Hospital nephrology kinshasa Democratic Republic of Congo -
yannick nlandu yannicknlandu@yahoo.fr Kinshasa University Hospital nephrology kinshasa Democratic Republic of Congo *
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In intensive care units (ICUs), renal dysfunction increases the risk of death, yet simple stratification tools are limited in low-resource settings. The value of admission serum creatinine as a predictor of in-hospital ICU mortality was assessed. 

This was a monocentric, retrospective cohort study conducted at the Cliniques Spécialisées de Kinshasa in the Democratic Republic of the Congo (DRC) from 1 January 2024 to 1 January 2025. Adults (aged ≥18 years) with an admission creatinine level measured by the Jaffé method were included, while those with stage 5D chronic kidney disease (CKD) were excluded. The optimal creatinine threshold for predicting death was determined using ROC curves and the Youden index. Cox regression was used to study predictors of mortality.

Of the 253 patients included in the study, 31 (12.3%) died. The best-performing admission creatinine threshold for predicting mortality was 1.4 mg/dL (≈124 µmol/L). Compared with patients with creatinine levels of ≤1.4 mg/dL, those with levels of >1.4 mg/dL had a higher in-hospital mortality rate (20.8%) and more frequent comorbidities (e.g. sepsis, heart failure and stroke). Multivariate analysis revealed that creatinine levels above 1.4 mg/dL were independently associated with death (hazard ratio (HR) 6.39; 95% confidence interval (CI) 2.30–17.72), as were age above 65 years, sepsis, heart failure, and stroke (significant HR). 

In this African setting, admission creatinine levels of more than 1.4 mg/dL indicate a high risk of in-hospital ICU mortality. This simple and widely available marker can provide early risk stratification and guide the intensification of care. However, multicentre validation with standardization of assays is required.

Kewords