FAMILY HISTORY AND NATURAL HISTORY OF HEMATURIA

 

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FAMILY HISTORY AND NATURAL HISTORY OF HEMATURIA

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Kazuya
Ogawa
Kazuya Ogawa ogwkzy@oita-u.ac.jp Fukuoka Children's Hospital Nephrology Fukuoka Japan *
Shinya Suematsu vanjack01@gmail.com Fukuoka Children's Hospital Nephrology Fukuoka Japan -
Yuka Watanabe symadeinheaven0110@gmail.com Fukuoka Children's Hospital Nephrology Fukuoka Japan -
Yoshitsugu Kaku y_kaku@nifty.com Fukuoka Children's Hospital Nephrology Fukuoka Japan -
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Hematuria is a common urinary abnormality, and some patients have a family history of hematuria. However, aside from a few hereditary disorders, the relationship between family history and the natural history of hematuria remains unclear. This study aimed to investigate the association between family history and spontaneous resolution of hematuria over a 10-year follow-up period in patients who were managed conservatively without therapeutic intervention at our institution.

Between January 1 and December 31, 2015, 150 patients presented to our department with hematuria. Of these, 30 patients who were judged to have no abnormal findings or who did not return after the initial visit, and 18 who required treatment, were excluded. The remaining 102 patients were retrospectively analyzed using medical records up to October 2025. Family history of hematuria was assessed up to second-degree relatives. The duration until disappearance of hematuria was analyzed, and comparisons were made according to the presence or absence of family history.

The median age at the initial visit was 7.4 years (47 boys, 55 girls), with a mean observation period of 52 months. In 79 cases, hematuria was first detected during school urine screening. A family history of hematuria was identified in 45 patients (44.1%; 17 boys, 28 girls), with a median age at presentation of 6.6 years. Hematuria persisted significantly longer in patients with a family history than in those without (p = 0.0003, log-rank test). The same trend was observed when analyzed separately by sex, whereas no significant difference was found among patients aged 7 years or older.

Hematuria persisted for a longer period in patients with both a younger age at onset and a positive family history, suggesting a potential genetic predisposition leading to earlier detection and prolonged urinary abnormalities. As recent studies have reported that familial hematuria is not always benign, careful and detailed assessment of family history, together with close long-term follow-up, is warranted—particularly in younger children presenting with urinary abnormalities.

Kewords