PATTERN OF GLOMERULONEPHRITIS (GN) IN SYLHET: A SINGLE CENTRE STUDY

 

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https://storage.unitedwebnetwork.com/files/1099/dd5dd6c90218f02eb940b57685713b10.pdf
PATTERN OF GLOMERULONEPHRITIS (GN) IN SYLHET: A SINGLE CENTRE STUDY

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Rita Rani
Paul
Rita Rani Paul ritapaul.pathologist@gmail.com Jalalabad Ragib-Rabeya Medical College and Hospital Pathology sylhet Bangladesh *
Sourav Paul Chowdhury chy.sourav@yahoo.com Oasis Hospital Nephrology sylhet Bangladesh -
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Glomerulonephritis (GN) encompasses a wide spectrum of renal pathologies with varying clinical presentations and histological patterns. Regional data is essential to understand the local disease burden and guide management. This study aims to identify the histological patterns of GN in patients undergoing renal biopsy in a tertiary center in Sylhet, Bangladesh.

This observational study was conducted using retrospective data collected from medical records. A total of 52 patients who underwent renal biopsy between 1st July 2023 and 31st December 2024 at a tertiary center in Sylhet were included. Patients aged between 11 and 70 years were studied. Demographic data, biopsy results, and renal function (serum creatinine) were analyzed.

Among 52 patients, 25% were male (13) and 75% female (39). The most frequent histological diagnosis was Lupus Nephritis Class IV (27%, 14 patients), followed by Focal Segmental Glomerulosclerosis (FSGS) (23%, 12 patients)Membranous Nephropathy (13.5%, 7)Lupus Nephritis Class III (5.8%, 3), and Class II (3.8%, 2). Other findings included Diffuse Membranoproliferative GN (7.7%, 4)IgA Nephropathy (5.8%, 3)Immune Complex-Mediated GN (3.8%, 2)Crescentic GN (5.8%, 3)Minimal Change Disease (1.9%, 1), and Renal Amyloidosis (1.9%, 1)13.5% (7 patients) had elevated serum creatinine, including cases of Amyloid Kidney (1.9%)FSGS (1.9%)Immune Complex GN (1.9%)IgA Nephropathy (1.9%), and Crescentic GN (5.8%, 3 patients).

Lupus nephritis, particularly Class IV, was the most prevalent GN pattern in this study, with a female predominance. FSGS and membranous nephropathy were also common. Notably, a significant proportion of patients exhibited elevated serum creatinine, particularly those with Crescentic GN, indicating advanced renal dysfunction. The high prevalence of Lupus Nephritis underscores the need for targeted screening and early intervention in this region. These findings provide crucial local epidemiological data, emphasizing the importance of renal biopsy in guiding diagnosis and management. Further large-scale studies are recommended to explore etiological factors, optimize treatment strategies, and improve renal outcomes this region.

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