CORRELATION OF THE SYSTEMIC INFLAMMATION RESPONSE INDEX AND AGGREGATE INDEX OF SYSTEMIC INFLAMMATION WITH THE MALNUTRITION INFLAMMATION SCORE IN ASSESSING MALNUTRITION IN PATIENTS UNDERGOING HEMODIALYSIS

 

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https://storage.unitedwebnetwork.com/files/1099/e5b7c44696390db4f9d9d879125a954b.pdf
CORRELATION OF THE SYSTEMIC INFLAMMATION RESPONSE INDEX AND AGGREGATE INDEX OF SYSTEMIC INFLAMMATION WITH THE MALNUTRITION INFLAMMATION SCORE IN ASSESSING MALNUTRITION IN PATIENTS UNDERGOING HEMODIALYSIS

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Dinda
Andini
Dinda Andini dindaandini.md@gmail.com Padjadjaran University Internal Medicine Bandung Indonesia *
Ria Bandiara ria.bandiara@unpad.ac.id Padjadjaran University Internal Medicine Bandung Indonesia -
Lilik Sukesi lilik.sukesi@gmail.com Padjadjaran University Internal Medicine Bandung Indonesia -
 
 
 
 
 
 
 
 
 
 
 
 

In hemodialysis patients, multiple factors contribute to the development of malnutrition. The Malnutrition - Inflammation Score (MIS), a validated, chronic kidney disease specific nutritional scoring system. Recently, hematological indices such as the Systemic Inflammation Response Index (SIRI) and Aggregate Index of Systemic Inflammation (AISI), have emerged as practical biomarkers for systemic inflammation. However, their direct correlation with malnutrition, specifically as assessed using MIS in hemodialysis settings, remains unclear.

We conducted a cross sectional analysis involving 120 maintenance hemodialysis patients. Inclusion criteria included patients with MIS, hematology, and anthropometry parameters. Spearman's correlation was used to analyze the relationship between MIS, SIRI, and AISI. Ethical approval was granted, and the study adhered to the principles of the Declaration of Istanbul on Organ Trafficking and Transplant Tourism.

Figure 1. Scatter plot of the correlation between the Inflammation Index and MISTable 1. Basic Characteristics of Routine Hemodialysis PatientsTable 2. Hematology and Biochemistry Laboratory ParametersTable 3. Distribution of Hematologic Inflammatory Indices and MIS ValuesTable 4. Correlation between Inflammatory Indices and MISPatients mean age was 49.8 + 15.2 years, with a higher proprotion of females (55%). The most common comorbidities are hypertension (77.5%) and diabetes mellitus (23.3%). The proportion of patients with malnutrition, defined by MIS > 6, reached 38.3 %. The median MIS was 5 (range: 1-15), AISI 284.7 (range: 28.2-3,189.7), and SIRI 1.25 (range: 0.16-18.5), and reflects the heterogenous status of inflammation. There was no significant correlation between MIS and the hematological inflammation indices, SIRI (r= -0.0025; p=0.783), nor AISI (r= -0.081; p=0.380) Adequacy of dialysis (Kt/V) was the only variable significantly correlates with lower SIRI (r= -0.236; p= 0.009) and AISI (r= -0,233; p= 0.014).

SIRI and AISI were not significantly correlated with MIS in this study. Although SIRI and AISI provide accessible assessments of systemic inflammation, neither is reliable biomarkers for malnutrition as measured by MIS. Adequacy of dialysis appears to contribute to lower level of inflammatory markers. A multifactorial approach remains important in the monitoring and management of nutrition and inflammation among hemodialysis patients.

Kewords