FACTORS ASSOCIATED WITH BLOOD FLOW VOLUME (Qa), RESISTANCE INDEX (RI), AND PULSATILITY INDEX (PI) IN LONG-TERM HEMODIALYSIS PATIENTS: A CROSS-SECTIONAL STUDY

 

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FACTORS ASSOCIATED WITH BLOOD FLOW VOLUME (Qa), RESISTANCE INDEX (RI), AND PULSATILITY INDEX (PI) IN LONG-TERM HEMODIALYSIS PATIENTS: A CROSS-SECTIONAL STUDY

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Herlina
Herlina
Herlina Herlina herlinadr21@gmail.com Padjadjaran University Internal Medicine Bandung Indonesia *
Rudi Supriyadi rudi.supriyadi@unpad.ac.id Padjadjaran University Internal Medicine Bandung Indonesia -
Lilik Sukesi lilik.sukesi@gmail.com Padjadjaran University Internal Medicine Bandung Indonesia -
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The effectiveness of hemodialysis largely relies on the proper function of an arteriovenous fistula (AVF), defined by sufficient blood flow and low vascular resistance. Nevertheless, evidence regarding the factors influencing Doppler ultrasonography (DUS) findings in long-term (≥5 years) hemodialysis (HD) patients in Indonesia remains scarce. The aim of this study is to assessing determinants of AVF characteristics, including blood flow volume (Qa), resistance index (RI), and pulsatility index (PI), as measured by DUS in long-term hemodialysis patients.

Cross-sectional study, 51 adult patients receiving maintenance hemodialysis via native AVF at a tertiary referral center were evaluated. Blood flow (Qa), resistance index (RI), and pulsation index (PI) were assessed using DUS. Demographics, comorbidities, dialysis parameters (duration, Kt/V), serum markers (calcium, phosphorus, albumin, hemoglobin), and Malnutrition-Inflammation Score (MIS) were recorded. Spearman and Pearson correlation analyses examined associations between technical characteristics, Qa, RI, PI, and Qa/RI ratio and continuous variables. Binary logistic regression identified independent predictors.


Figure 1. Scatter-plot between diameter and Qa (Flow Q, mL/minute)Figure 2. Scatter-plot between albumin and RITable 1. Baseline Characteristics of Hemodialysis PatientsTable 2. Distribution of AVF parameters by Doppler ultrasound (DUS)Table 3. Correlation between demographic, clinical, anatomical, and technical AVF characteristics and Qa, RI, PI, and the Qa/RI ratioTable 4. Multiple linear regression for Qa (Flow Q, mL/min)Table 5. Simple linear regression for RI ~ albuminTable 6. Multiple linear regression for Qa/RI ratioTable 7. Simple linear regression for RI (dependent) with tortuousityAVF location showed a significant negative correlation (r = −0.396; p = 0.004), where radiocephalic fistulas (RC) had lower blood flow compared to brachiocephalic fistulas (BC). Analysis of the RI showed that only albumin had a significant positive correlation (r = 0.285; p = 0.043). The Qa/RI ratio value was positively correlated with vascular diameter (r = 0.367; p = 0.008), aneurysm (r = 0.353; p = 0.011), and underlying Chronic Pyelonephritis disease (PNC) (r = 0.326; p = 0.020). In contrast, the AVF location showed a negative correlation (r = −0.422; p = 0.002), suggesting that distal fistulas (RC) had a lower Qa/RI ratio than proximal fistulas (BC). Phosphorus levels appeared to have a slight negative relationship with the Qa/RI ratio (p = 0.061). Tortuousity had a significant positive correlation with PI (r = 0.394; p = 0.004) and calcification showed a trend towards increased PI (r = 0.245; p = 0.083), although not statistically significant. 

Anatomical and technical factors of the AVF (especially diameter, presence of aneurysm, tortuousity, and fistula location) had the strongest influence on DUS functional indicators (Qa, Qa/RI, and PI). Clinical and laboratory factors such as albumin showed a limited relationship only with RI, while other factors such as age, gender, duration of HD, Body Mass Index (BMI), and Kt/V did not have a significant effect. 

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