CORRELATION BETWEEN HAEMODIALYSIS ADEQUACY AND QUALITY OF LIFE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS IN BATU INDONESIA

 

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https://storage.unitedwebnetwork.com/files/1099/c26732fef3dfdf56c840f04a4d76e837.pdf
CORRELATION BETWEEN HAEMODIALYSIS ADEQUACY AND QUALITY OF LIFE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS IN BATU INDONESIA

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Dyah Retno
Wulandari
Dyah Retno Wulandari dyahretnosppd@gmail.com Universitas Airlangga-dr Soetomo General Academic Hospital Nephrology Surabaya Indonesia *
Artaria Tjempakasari artnerf@yahoo.com Universitas Airlangga-dr Soetomo General Academic Hospital Nephrology Surabaya Indonesia -
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Chronic kidney disease (CKD) is a progressive condition affecting over 10% of the global population, equating to more than 800 million individuals. In Indonesia, the prevalence of CKD is reported to be 0.5%. Furthermore, the number of patients undergoing kidney replacement therapy (KRT), primarily through hemodialysis, has been rapidly increasing, with over 132,000 cases reported in 2018. Hemodialysis adequacy can enhance the quality of life, increase social activity, and reduce inability and mortality in chronic kidney disease patients. This study compares the hemodialysis adequacy methods in relation to quality of life using KDQOL SF 36.

This is a cross-sectional study over 70 hemodialysis patients in Karsa Husada General Hospital, Indonesia. Hemoadialysis adequacy was obtained using URR (≥65%), Online Clearance Monitoring (OCM) (≥1,2), and Daugirdas Kt/V (≥1,2) from calculating by Daugirdas formula. The quality of life measured using KDQOL-36 scoring system.


There were 70 hemodialysis patients that meet the inclusion criteria, which 35  patients (50%) were male, and 35  patients (50%) were female. The demographic and clinical subject characteristic as seen on table 1.

Table 1. Demographic and Clinical Subject Characteristics

Variable

Number (N)

Prosentase (%)

Age (years)

 

< 40 years

2

2,86

 40 - < 60 years

42

60,00

≥ 60 years

26

37,14

Gender

70

100,00

Male

35

50,00

Female

35

50,00

BMI (kg/m2)

Underweight

10

14,29

Normoweight

36

51,43

Overweight

18

25,71

Obesity

6

8,57

Hemodialysis Duration (hours)

5 hours

69

98,57

< 5 hours

1

1,43

Vascular Access

AV Fistula

62

88,57

CDL

4

5,71

Manual Access

4

5,71

Blood Pressure

Systolic Blood Pressure (SBP)

SBP < 140 mmHg

17

24,29

SBP 140 sd <160 mmHg

15

21,43

SBP ≥160 mmHg

38

54,29

Dyastolic Blood Pressure (DBP)

DBP < 90 mmHg

33

47,14

DBP 90 sd <100 mmHg

16

22,86

DBP ≥100 mmHg

21

30,00

Haemoglobin

Hb>10 mg/dL

11

15,71

HB 7-10 mg/dL

58

82,86

Hb <7

1

1,43

The Mean values of hemodialysis adequacy were as follow: URR (70,89%±7,79%), OCM (1,49±0,10), Daugirdas Kt/V (1,5±0,34), and the mean values of quality of life using KDQOL-36 scores was 538.57 ± 31.97. The correlation between hemodialysis adequacy and quality of life, is shown in Table 2, which indicates that neither OCM, URR, nor Daugirdas Kt/V shows a correlation with quality of life. However, a sub-analysis showed a correlation between body pain and hemodialysis adequacy using URR (r=0.282, p=0.018) and Daugirdas Kt/V (r=0.212, p=0.011).

Table 2. Correlation of Hemodialysis Adequacy with Quality of Life (KDQOL SF 36)

Method

Mean

r

p

OCM

1.49±0.10

-0.072

0.903

KDQOL SF-36

538.57 ± 31.97

URR

70.89%±7.79%

0.084

0.347

KDQOL SF-36

538.57 ± 31.97

Daugirdas Kt/V

1.5±0.34

0.110

0.409

KDQOL SF-36

538.57 ± 31.97


This study showed no correlation between hemodialysis adequacy and overall quality of life; however, the pain subscale showed a significant correlation.

Kewords