THE PROGNOSTIC VALUE OF THE SERUM SODIUM-TO-CHLORIDE RATIO IN PATIENTS HOSPITALIZED WITH HEART FAILURE AND ACUTE KIDNEY INJURY: A RETROSPECTIVE COHORT STUDY

 

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THE PROGNOSTIC VALUE OF THE SERUM SODIUM-TO-CHLORIDE RATIO IN PATIENTS HOSPITALIZED WITH HEART FAILURE AND ACUTE KIDNEY INJURY: A RETROSPECTIVE COHORT STUDY

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Julio Ismael
Pech Cruz
Julio Ismael Pech Cruz julioismael95@hotmail.com Instituto Nacional de Cardiología Dr Ignacio Chávez Nephrology Mexico City Mexico *
Natalia Adela García Paguay ngarciaec@gmail.com Instituto Nacional de Cardiología Dr Ignacio Chávez Nephrology Mexico City Mexico -
Victor Hugo Gómez-Johnson vgomezjohnson@gmail.com Instituto Nacional de Cardiología Dr Ignacio Chávez Nephrology Mexico City Mexico -
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Electrolytes imbalances are a hallmark in heart failure. A higher serum sodium-to-chloride (Na/Cl) ratio reflects hypochloremia and may be a stronger predictor of adverse outcomes than serum sodium and chloride alone. Few studies have evaluated its prognostic significance in heart failure. The aim of our study was to assess the association between the serum Na/Cl ratio at hospital admission and clinical outcomes in patients hospitalized for acute decompensated heart failure (ADHF) with acute kidney injury (AKI).

This was a retrospective study conducted at a tertiary care hospital. Patients aged >18 years who were admitted for ADHF with AKI between October and September 2025 were included. Patients were divided into two Na/Cl ratio groups based on the cut-off point determined by the ROC curve. The ANOVA and Kruskal-Wallis tests were used to compare continuous variables among groups, while the chi-square test was used for categorical variables. We assessed the relationship between the admission Na/Cl ratio and the occurrence of in-hospital mortality. 

A total of 41 patients were included; 65.9% were women, and the mean age was 62 years. ROC curve analysis showed that the Na/Cl ratio had greater sensitivity in predicting in-hospital mortality compared with serum sodium and serum chloride levels (0.712 vs. 0.629 and 0.418, respectively), with a cut-off point of 1.38. Between Na/Cl ratio groups, there was no difference in most biochemical parameters and treatments, except for serum chloride levels at admission, day 1, and day 2 of hospitalization, which were lower in the Na/Cl ratio ≥ 1.38 group. In-hospital mortality was more common in the group of Na/Cl ≥ 1.38 (52.9% vs 16.7%, p = 0.014), with an odds ratio of 5.625 (95% interval confidence 1.339 to 23.625, p = 0.0183). 

In patients admitted for ADHF with AKI, those with an admission Na/Cl ratio ≥ 1.38 had a higher risk of in-hospital mortality. The Na/Cl ratio, which reflects hypochloremia, should be considered at admission to help determine patient prognosis.

Kewords