CHANGES OF SHORT- AND MEDIUM-CHAIN FATTY ACIDS LEVELS LINKED TO INFLAMMATION, UREMIA, AND MICROBIOTA IMBALANCE IN CHRONIC KIDNEY DISEASE

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https://storage.unitedwebnetwork.com/files/1099/eb16ab678b03b5d9f8cab95f125ea33a.pdf

Abstract Title *

CHANGES OF SHORT- AND MEDIUM-CHAIN FATTY ACIDS LEVELS LINKED TO INFLAMMATION, UREMIA, AND MICROBIOTA IMBALANCE IN CHRONIC KIDNEY DISEASE

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Co-author 1

Chen-Mei Chang sinthdora@gmail.com Taipei Medical University Hospital, Taipei, Taiwan Division of Nephrology, Department of Internal Medicine Taipei Taiwan *

Co-author 2

Kai-Jie Yang kjie.yang@gmail.com Taipei Medical University Hospital, Taipei, Taiwan Taipei Medical University-Research Center of Urology and Kidney (TMU-RCUK) Taipei Taiwan -

Co-author 3

Mai-Szu Wu sinthdora@gmail.com Taipei Medical University Hospital, Taipei, Taiwan Taipei Medical University-Research Center of Urology and Kidney (TMU-RCUK) Taipei Taiwan -

Co-author 4

I-Wen Wu filawu@yahoo.com Taipei Medical University Hospital, Taipei, Taiwan Division of Nephrology, Department of Internal Medicine Taipei Taiwan -

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Introduction

Chronic kidney disease (CKD) is closely linked to gut dysbiosis, with changes in short-chain fatty acid (SCFA) levels implicated in disease progression. However, detailed SCFA profiling and microbial correlations in Asian CKD populations remain limited.

Methods

In this cross-sectional study, 100 adult participants (80 CKD and 20 non-CKD controls) were enrolled. Serum SC/MCFA levels, including acetic acid, propionic acid, isobutyric acid, decanoic acid were quantified via gas chromatography-mass spectrometry. Gut microbiota composition was assessed using 16S rRNA sequencing. Correlation analyses were performed between individual SCFA & MCFA concentrations and specific bacterial taxa, metabolic markers, and CKD status.

Results

The mean age of population was 64.15 years old, 46% were man, 47% had T2DM, the mean eGFR was 59.68mL/min/1.73 m2. There is significant changes in microbiota composition and diversity between controls and CKD patients. The relative abundances of genus Alistipes, particularly Alistipes indistinctus, Alistipes obesi, Alistipes putredinis, Alistipes sp. An31A showed significant positive correlations with the serum concentrations of these four SC/MCFA. From 11 SC/MCFA, only the serum levels of Isobutyric acid, Heptanoic acid, Nonanoic acid and decanoic acid were significantly different between controls and CKD patients. Pearson correlation analysis revealed significant associations between these 4 SC/MCFA levels and clinical data, bacterial species, immunomarker and serum amino acids levels.

Conclusion

The SC/MCFA are heterogenous group of acids with distinctive roles in CKD. Isobutyric, Heptanoic and Nonanoic acid are positively correlated with renal function, inflammation and uremic toxins. Decanoid acids were decreased in CKD patients. Replenishment of Alistipes sp. An31A with control of Phenylalanine, Asparagine, and Aspartic Acid may be a potential direction to increase this fatty acid.

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