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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
INTRODUCTION: Kidney transplantation is the best therapy for end-stage renal disease. After transplantation, it is important to monitor patients closely because kidney graft survival may be limited by factors such as delayed graft function, rejection events, and graft fibrosis. In pos-transplant protocol biopsies, an increase in macrophage infiltration in the renal parenchyma correlates with the severity of renal dysfunction. Likewise, macrophage infiltration precedes the production of TGFβ and fibrosis, so it has been proposed that this could have a prognostic value for subsequent graft survival. OBJECTIVE: This study aimed to evaluate a possible correlation between serum and renal tissue TGFβ1 levels with interstitial fibrosis in a cohort of kidney transplant patients from January 2022 to September 2023.
METHODS. Cohort prospective study, 40 Patients (19 living-donor kidney transplant and 21 deceased-donor kidney transplant) underwent protocol biopsies at three months and one-year pos-transplant. Banff 2022 was employed for histologic evaluation, renal tissue TGFβ1 levels were measured by immunohistochemistry in a semi-quantitive form in 5 categories: 0=negative, 1=positive+, 2=positive++, 3=positive+++ 4=positive++++ and serum levels by the ELISA technique at both time points. Subsequently, the correlation of serum and renal TGFβ1 levels with interstitial fibrosis/tubular atrophy observed in protocol biopsies was performed.
RESULTS: Mean age was 41.4 ±14.1, 21- 61 years in living-donor kidney transplant and 24-75 years in deceased-donor kidney transplant (p=0.028). Cold ischemia time was 83.5 ± 57.8 minutes in living-donor kidney transplant, and 793.6 ± 249.3 minutes in deceased-donor kidney transplant (p=<0.001). Pretransplant Class II Panel Reactive Antibody was higher in in deceased-donor kidney transplant (p=0.039). Glomerular filtration rate (CKD-EPI 2021) at 3 and 12 months postransplant was not significantly different. Twelve patients had kidney rejection, the most frequent was subclinical humoral rejection. Kidney survival was 100% at 12 months. The results showed a positive correlation between TGFβ1 expression levels in the intersticium and the presence of IFTA at three months post-transplant. (p=0.005). For the year post-transplant, the interstitial increase in TGFβ1 levels had a tendency correlation with the rise in fibrosis in the biopsy (p=0.070). On the other hand, a tendency was observed in patients who did not develop rejection to have lower serum levels or lower intensity of TGFβ1 expression in the biopsy (p=0.037).
CONCLUSION: TGFβ1 serum levels no correlate with IFTA, but there is a positive correlation between TGFβ1 expression levels with IFTA degree and rejection in biopsies at three months pos-transplant.
