Impact of clinical factors and hemostatic agents on bleeding risk in kidney biopsy: A scoring model to guide minimal hospitalization

 

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https://storage.unitedwebnetwork.com/files/1099/2980e1f2fd6702987d2ef419641b097f.pdf
Impact of clinical factors and hemostatic agents on bleeding risk in kidney biopsy: A scoring model to guide minimal hospitalization

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Rena
Suzukawa
Rena Suzukawa renasuzukawa@gmail.com Institute of Science Tokyo Nephrology Tokyo Japan *
Daiei Takahash d.takahashi@musashino.jrc.or.jp Musashino Red Cross Hospital Nephrology Tokyo Japan -
Takanori Hasegawa tk.hasegawa@gmail.com Institute of Science Tokyo M&D Data Science Center Tokyo Japan -
Yurina Yataka y.yurina16@gmail.com Musashino Red Cross Hospital Nephrology Tokyo Japan -
Mizuki Watada watadamizuki415@gmail.com Musashino Red Cross Hospital Nephrology Tokyo Japan -
Motoki Hoshino athcks77xear@yahoo.co.jp Musashino Red Cross Hospital Nephrology Tokyo Japan -
Wakana Shoda wakanashoda@gmail.com Musashino Red Cross Hospital Nephrology Tokyo Japan -
Tamaki Kuyama tamaki.kuyama@gmail.com Musashino Red Cross Hospital Nephrology Tokyo Japan -
Kiyohide Fushimi kfushimi.hci@tmd.ac.jp Institute of Science Tokyo Health Policy and Informatics Tokyo Japan -
Shinichi Uchida suchida.kid@tmd.ac.jp Institute of Science Tokyo Nephrology Tokyo Japan -
Shintaro Mandai smandai.kid@tmd.ac.jp Institute of Science Tokyo Nephrology Tokyo Japan -
 
 
 
 

The hospital stay following percutaneous kidney biopsy (PKB) is convention-based, lacking risk-based criteria. We aimed to develop a practical scoring tool to optimize hospitalization.

We conducted a retrospective cohort study using a nationwide administrative claims inpatient database (2016–2021). We included adults undergoing native PKB, excluding transplant recipients and extreme BMI (<15 or ≥50). The primary outcome was major bleeding (transfusion or surgical/endovascular intervention within 6 days after biopsy). Logistic regression assessed the association of clinical diagnosis and hemostatic agents with bleeding risk. The ridge regression model was built using training data from four Japanese regions, and the regularization parameter was selected through 10-fold cross-validation. Variables with large coefficients were used to construct the Kidney biopsy Blood transfusion Index for Triage (K-BIT). External validation was performed using data from two additional regions.

Among 85,450 patients (median age 58; hospital day 6), 1.99% had major bleeding. Compared to chronic glomerulonephritis, bleeding risk was highest in rapidly progressive glomerulonephritis or ANCA-associated vasculitis (adjusted OR 8.95; 95% CI, 7.41–10.82) and acute kidney injury (OR 14.52; 95% CI, 11.65–18.10). Hemostatic agents were used in 53.6% of patients. Carbazochrome sulfonate (OR, 0.69; 95% CI, 0.58–0.85) and its combination with tranexamic acid (OR, 0.79; 95% CI, 0.69–0.90) were associated with reduced bleeding risk, particularly in the subgroup population with proteinuria or nephrotic syndrome. In the test dataset, K-BIT (range –1 to 10) incorporates age, diagnosis tier, BMI, and medication (Figure). In the external validation cohort, scores ≤2 (57.1% of cohort; low and very low risk category) had a bleeding risk of 0.50%, compared with 1.91% overall. If all patients were discharged same-day, the bleeding risk would be 1.91%. Restricting early discharge to scores ≤2 achieves an event rate of 0.5% and reduces hospitalization by 342 days per 100 patients, supporting substantial resource savings while maintaining patient safety (Figure). 

Pre-biopsy clinical diagnosis and age are strong predictors of bleeding risk. Hemostatic agents, especially carbazochrome-based regimens, may reduce the bleeding risk. K-BIT score offers safe short-stay PKB and substantial resource savings.

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