“Relationship between Body Composition Assessed by Bioelectrical Impedance, Hydration Status, and Hemodialysis: Significant Correlations Between Hydration, Phase Angle, and Hemoglobin”

 

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“Relationship between Body Composition Assessed by Bioelectrical Impedance, Hydration Status, and Hemodialysis: Significant Correlations Between Hydration, Phase Angle, and Hemoglobin”

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Juan Daniel
Diaz Garcia
Ana Elena Gomez Sanchez Alvarez anagsa08@gmail.com Hospital General de Mexico "Dr. Eduardo Liceaga" nephrology Ciudad de Mexico Mexico -
Juan Daniel Diaz Garcia drdanieldiaz.nefrologia@gmail.com Hospital General de Mexico "Dr. Eduardo Liceaga" nephrology Ciudad de Mexico Mexico *
Linnys Alcantara Quiroga Linnys.q@gmail.com Hospital General de Mexico "Dr. Eduardo Liceaga" nephrology Ciudad de Mexico Mexico -
Laura Fuentez Mendez laufuentesmendez@gmail.com Hospital General de Mexico "Dr. Eduardo Liceaga" nephrology Ciudad de Mexico Mexico -
Lucia Monserrat Perez Navarro plucymonsen@gmail.com Hospital General de Mexico "Dr. Eduardo Liceaga" Research methodology Ciudad de Mexico Mexico -
Gloria Guadalupe Garcia Villalobos gvillalobosgloria@gmail.com Hospital General de Mexico "Dr. Eduardo Liceaga" nephrology Ciudad de Mexico Mexico -
Eduardo Guerrero Hinzpeter eduardeg.90@gmail.com Hospital General de Mexico "Dr. Eduardo Liceaga" nephrology Ciudad de Mexico Mexico -
Enrique Jose Antonio Robiou Vivero enriquerobiou@gmail.com Hospital General de Mexico "Dr. Eduardo Liceaga" nephrology Ciudad de Mexico Mexico -
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Chronic Kidney Disease (CKD) leads to the need for renal replacement therapy (Hemodialysis - HD), commonly associated with high rates of morbidity, often driven by volume overload. The excess of intravascular and extravascular volume in CKD patients is linked to hypertension and cardiac overload, and it is hypothesized that there is a well-established interrelation between nutritional status and anemia. The Bioimpedance Vector Analysis (BIVA) emerges as an objective tool to assess and manage the body composition and hydration status, overcoming the limitations of traditional methods. The aim of this study is to characterize these factors and analyze their correlations in a cohort of HD patients.

An observational, analytical, cross-sectional study was conducted on 33 patients enrolled in an HD program. Each patient underwent a pre-dialysis BIVA assessment to determine fluid compartments (Total Body Water - TBW, Extracellular Water - ECW), Phase Angle (nutritional status), and Visceral Fat. Simultaneously, dialysis session parameters (Ultrafiltration - UF) and laboratory values (Hemoglobin - Hb) were recorded.

Table of categories and variables

The study population (60.6% women, mean age 35.3 years) showed a high prevalence of subclinical overhydration (54.5% with elevated ECW/TBW ratio). Only 27.3% achieved adequate ultrafiltration. An extremely strong and significant negative correlation was found between the Extracellular Water percentage (ECW/TBW) and the Phase Angle (r= -0.911, p<0.001), indicating that greater overhydration is associated with poorer nutritional status. Furthermore, a significant negative correlation was found between the ECW/TBW ratio and hemoglobin levels (r= -0.403, p= 0.020). The dialysis sessions in (HD) patients were effective, significantly reducing weight, blood pressure (systolic and diastolic), and heart rate.

Body composition analysis in patients with chronic kidney disease has gained interest in recent years due to its significant impact as a risk factor for morbidity and mortality. Our results confirm the existence of an association between overhydration, malnutrition/inflammation (low phase angle), and anemia in HD patients. The strong correlation found suggests that inadequate fluid management is a central factor exacerbating other complications. For this reason, some body composition parameters obtained by BIVA, such as the percentage of extracellular water and phase angle (ECW/TBW), could be considered in combination as potential tools to assess the nutritional status of dialysis patients. Routine implementation of bioimpedance is crucial for an objective assessment of dry weight and comprehensive patient management. It allows us to verify that, in some cases, the clinical assessment is biased, and in other cases, it allows us to improve hemodynamic tolerance.

Kewords