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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
The Selectivity Index (SI) is commonly used to differentiate minimal change disease (MCD) from other forms of nephrotic syndrome (NS). However, the diagnostic validity of SI remains insufficiently established. We analyzed the diagnostic utility of SI and its association with the response to steroid (prednisolone, PSL) therapy for each underlying NS etiology.
Eighty-one patients with NS who underwent renal biopsy between 2022 and 2024 were analyzed. We examined the relationships among SI, clinical characteristics at the time of biopsy, and the remission rate (complete and partial remission type I) within six months after initial treatment with PSL.
The distribution of primary NS was as follows: MCD 48%, membranous nephropathy (MN) 33%, focal segmental glomerulosclerosis (FSGS) 9%, membranoproliferative glomerulonephritis (MPGN) 6%, and IgA nephropathy 4%. NS patients with SI ≤0.2 was observed in 60% of MN and 76% of MCD cases, indicating that SI had low diagnostic utility for MCD. Furthermore, MCD cases presenting with acute kidney injury (AKI) at onset showed lower selectivity compared with other MCD cases. The remission rates following initial treatment for each underlying disease were as follows: MCD 88%, MN 28%, FSGS 18%, and MPGN 10%. Among patients who achieved complete remission, 75% had an SI <0.2, while this proportion was only 35% in those with partial remission.
Present study demonstrated that SI had limited diagnostic utility for MCD and showed lower selectivity in cases presenting with AKI. Regardless of the underlying disease, cases exhibiting highly selective proteinuria tended to achieve higher remission rates with initial immunosuppressive treatment, suggesting that SI may be useful for evaluating PSL treatment responsiveness rather than for disease differentiation.
