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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Overweight and obesity may accelerate kidney disease progression in autosomal dominant polycystic kidney disease (ADPKD), yet their prognostic implications remain unclear, particularly across sex and age subgroups. This study examined the impact of overweight/obesity on renal outcomes using an Attribute-Based Medicine (ABM) framework with cross-classification by sex and age, providing a precision-medicine approach to individualized risk assessment.
We analyzed 553 ADPKD patients not receiving renal replacement therapy (median age: 43 years; eGFR: 55.9 mL/min/1.73 m²; total kidney volume: 1335.4 mL). Overweight/obesity was defined according to body mass index (BMI) ≥25 kg/m². Patients were cross-classified by sex (men/women) and age (<50/≥50 years). The renal outcome—defined as a ≥30% decline in eGFR or initiation of renal replacement therapy—was evaluated using Cox regression. Mean follow-up duration was 6.9 years, during which 266 renal events occurred.
In the overall cohort, overweight/obesity was significantly associated with worse renal prognosis (HR=1.43, P=0.042). No significant interaction was observed between overweight/obesity and age ≥50 years in either sex (interaction P=0.928 in men, P=0.168 in women), though women showed a trend toward greater age-related effects. Using cross-classification, the association between overweight/obesity and kidney prognosis was particularly strong in women under 50 years (HR=3.20, P=0.004), followed by men under 50 (HR=1.82, P=0.037). In contrast, no significant associations were found in women aged ≥50 years (HR=0.51, P=0.177) or men aged ≥50 years (HR=1.30, P=0.576). These findings suggest a sex–age-dependent influence of metabolic stress on disease progression.
Overweight and obesity represent key modifiable risk factors for kidney function decline in ADPKD, particularly in younger individuals—most notably younger women. Attribute-Based Medicine (ABM) employing sex–age cross-classification reveals heterogeneous vulnerability patterns, offering actionable insights for precision nephrology and preventive strategies tailored to demographic attributes. Presented from the perspective of “Preserving Kidney Health,” this work extends prior findings and was previously presented at the American Society of Nephrology Kidney Week 2025 as an encore abstract.
