CORRELATION OF HISTOPATHOLOGICAL AND GLOMERULAR SCORE INDEX WITH PROTEINURIA IN NEPHROTIC SYNDROME SUBJECTS

 

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CORRELATION OF HISTOPATHOLOGICAL AND GLOMERULAR SCORE INDEX WITH PROTEINURIA IN NEPHROTIC SYNDROME SUBJECTS

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Akhyar
Albaar
Akhyar Albaar rvpakhyarmd@gmail.com InaSN Internal Medicine Hasanuddin University Makassar Indonesia *
Syakib Bakri syakib.bakri@yahoo.com InaSN Internal Medicine Hasanuddin University Makassar Indonesia -
Hasyim Kasim Hasyimkasim@yahoo.com InaSN Internal Medicine Hasanuddin University Makassar Indonesia -
Haerani Rasyid haeraniabdurasyid@yahoo.com InaSN Internal Medicine Hasanuddin University Makassar Indonesia -
Sitti Rabiul Zatalia Ramadhan zatalia_ramadhan@yahoo.com InaSN Internal Medicine Hasanuddin University Makassar Indonesia -
Nasrum Machmud nasrummachmud29@yahoo.com InaSN Internal Medicine Hasanuddin University Makassar Indonesia -
Khadijah Khaerunnisa ijhasho@gmail.com InaSN Internal Medicine Hasanuddin University Makassar Indonesia -
Achmad Fikry fikryfaridin24@gmail.com InaSN Internal Medicine Hasanuddin University Makassar Indonesia -
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Glomerulonephritis, histopathologically, consists of several types, with  the clinical sign being nephrotic syndrome (NS) which is based on the presence of proteinuria. Glomerular damage is described in different degrees by histopathological type. The degree of glomerular damage can be assessed by a glomerular score index (GI).

Study was evaluated biopsy data of subjects with clinical symptoms NS period January 2014 - May 2020 at Hasanuddin University Hospital. Histopathological examinated using light microscopy. Glomerular severity was assessed by GI which assessed disease activity (presence or absence of hypersellularity), disease severity (presence or absence of crescent) and distribution (focal / diffuse) with a range of GI scores between 0 - 8.

From a study of 49 SN subjects the most subject was male 27 (55.1%) and the most histopathological minimal lesion glomerulonephritis (MLGN) were 26 (53.1%) followed by focal segmental glomerulosclerosis (FSGS) 10 (20.4%), membranoproliferative glomerulonephritis (MPGN) 7 (14.4%) and membranous glomerulonephritis (MGN) 6 (12.1%) subjects. Membranoproliferative glomerulonephritis had the largest IG score and was significantly different fromother histopathologic types (LMGN, FSGS and GNM) (p = 0.02). Focal segmental glomerulosclerosis had a higher mean proteinuria excretion and was significantly different than other histopathological types (LMGN, MGN and MPGN) (p = 0.02). IG score was not significantly associated with proteinuria (p> 0.05).

Membranoproliferative glomerulonephritis has a significantly higher GI score than the other types (MLGN, FSGS and MGN) but both MPGN type and high GI scores are not correlated with the amount of proteinuria. Focal segmental glomerulosclerosis has a significantly higher amount of proteinuria than the other types (MLGN, MGN and MPGN).

Kewords