CLINICAL AND HISTOPATHOLOGICAL PROFILE OF GLOMERULAR DISEASES IN A TERTIARY CENTER IN SOUTHERN BRAZIL: ANALYSIS OF RENAL BIOPSIES FROM 2021 TO 2023

 

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https://storage.unitedwebnetwork.com/files/1099/f8d767e218d288e0f122b318dd04180b.pdf
CLINICAL AND HISTOPATHOLOGICAL PROFILE OF GLOMERULAR DISEASES IN A TERTIARY CENTER IN SOUTHERN BRAZIL: ANALYSIS OF RENAL BIOPSIES FROM 2021 TO 2023

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Augusto
Cesar Soares do Santos Junior
Raphael Hemann Palma raphael.palma@gmail.com Universidade Federal Ciencias da Saúde de Porto Alegre Nephrology Porto Alegre Brazil -
Rafaela Gageiro Luchesi Soares rafaelagls@ufcspa.edu.br Universidade Federal Ciencias da Saúde de Porto Alegre Medicine Porto Alegre Brazil -
Gisele Meinerz giselemeinerz01@gmail.com Universidade Federal Ciencias da Saúde de Porto Alegre Nephrology Porto Alegre Brazil -
Augusto Cesar Soares do Santos Junior acssjr@gmail.com Faculdade Ciências Médicas de Minas Gerais Medicine Belo Horizonte Brazil *
Elizete Keitel keitel@ufcspa.edu.br Universidade Federal Ciencias da Saúde de Porto Alegre Nephrology Porto Alegre Brazil -
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Glomerulonephritis represents a significant cause of chronic kidney disease, with renal biopsy playing a fundamental role in its diagnosis. In Brazil, comprehensive and systematized data remain limited, and previous reports commonly identify Focal Segmental Glomerulosclerosis (FSGS) as the most frequent glomerulopathy.

This was a descriptive study conducted at Santa Casa de Porto Alegre between 2021 and 2023, including adult patients who underwent kidney biopsy with a histological diagnosis of glomerulonephritis. Clinical, laboratory, and histological data of the included patients were analyzed.

A total of 366 patients were included. Over the study period, a 21% increase in the number of biopsies performed was observed. The main indication for biopsy was nephrotic syndrome, followed by non-nephrotic proteinuria, with or without hematuria. IgA nephropathy was the most prevalent glomerulopathy (20%), followed by FSGS and lupus nephritis.

Previous studies have reported an increasing prevalence of IgA nephropathy in Brazil.This single-center study from the Southeast of Brazil confirms a higher prevalence of IgA nephropathy as the most common glomerulopathy which may be partially explained by a shift in biopsy indications—particularly an increase in biopsies performed outside the context of nephrotic syndrome, such as those prompted by non-nephrotic range proteinuria

Kewords