THE IMPACT OF INTRADIALYTIC AEROBIC EXERCISE IN THE INCIDENCE OF FALLS AND FATIGUE IN PATIENTS TREATED WITH HEMODIALYSIS

 

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https://storage.unitedwebnetwork.com/files/1099/40653e08039cb350a124e6d1be99584b.pdf
THE IMPACT OF INTRADIALYTIC AEROBIC EXERCISE IN THE INCIDENCE OF FALLS AND FATIGUE IN PATIENTS TREATED WITH HEMODIALYSIS

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Ana Elizabeth
Figueiredo
Carolina Prado Lima Figueiredo carolina.figueiredo@edu.pucrs.br Pontifícia Universidade Católica do Rio Grande Do Sul School of Medicine Porto Alegre Brazil -
Vinicius da Silva Lessa de Oliveira lessaviniciusdeoliveira@gmail.com Pontifícia Universidade Católica do Rio Grande Do Sul School of Medicine Porto Alegre Brazil -
Ana Elizabeth Figueiredo anaef@pucrs.br Pontifícia Universidade Católica do Rio Grande Do Sul School of Life and Health Sciences Porto Alegre Brazil *
Carlos Eduardo Poli de Figueiredo cepolif@pucrs.br Pontifícia Universidade Católica do Rio Grande Do Sul School of Medicine Porto Alegre Brazil -
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Patients undergoing hemodialysis (HD) face elevated risks of falls and frequently suffer from significant post-dialysis fatigue. Falls are a major safety concern, as approximately 30% to 60% of HD patients experience a fall within one year, with recurrence estimated between 22% and 37%. While physical activity has demonstrated benefits in various populations, including the reduction of falls in frail older adults, there are few studies directly evaluating the effects of intradialytic aerobic exercise on fall incidence in this population. The aim of this study was to assess the impact of an intradialytic aerobic exercise program on the incidence of falls and fatigue in HD patients.

This was a randomized controlled clinical trial (RCT) involving forty-three patients recruited from a single HD unit. Patients were randomized into an Intervention Group (IG,n=17) and a Control Group (CG, n=26). Participants were older than 18 years old, had been on regular HD for over three months, were clinically stable, and did not practice regular, organized physical activity. The IG performed a supervised aerobic exercise program using a cycle ergometer for 30 minutes, twice a week, over twelve-week period. Exercise intensity was progressively increased from "light-to-moderate" in the first six weeks to "moderate-to-intense" in the last six weeks, based on the BORG Rating of Perceived Exertion Scale. The exercise generally began after the first hour of dialysis. The CG maintained their usual treatment routine without in-dialysis exercise. Self-reported falls were monitored weekly in both groups. Pre- and post-intervention outcomes included the incidence of falls, the Modified Fatigue Impact Scale (MFIS), the Six-Minute Walk Test (6MWT), and the Timed Up and Go (TUG) test.

The study was prematurely terminated due to a clear benefit observed in the falls outcome during an interim analysis. The intervention group (IG) showed a significant and representative reduction (96.4%) in the incidence of falls compared to the CG (10%), with strong statistical power (p<0.001; Power=0.984). The median number of falls before the intervention (3.35 fall/patient) significantly reduced in the IG post-intervention (0.12fall/patient). The IG did not show a significant reduction in self-reported fatigue levels (MFIS). However, the MFIS mean decreased significantly in both the CG (p<0.001) and the IG (p=0.006), although the magnitude of effect was small for the IG. There was no significant improvement in the TUG test in either group. The 6MWT (TC6) did show a significant improvement in the IG (p=0.014).

Intradialytic aerobic exercise is a viable, simple, and highly effective strategy for decreasing the incidence of falls in patients undergoing HD. This significant reduction in falls was observed despite the absence of a significant improvement in self-reported fatigue (MFIS) and most functional tests (TUG). This suggests that the mechanism for fall reduction may be attributed to other factors, such as improved balance, motor coordination, or hemodynamic stability.

Kewords