Back
For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".
To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".
During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
After identifying immunomarkers of acute injury, KIM-1 and LCN2, in all kidney biopsies from 31 patients with COVID-19 pneumonia and de novo kidney dysfunction, we investigated whether circulating markers of kidney epithelial injury are common in patients with laboratory-confirmed COVID-19 who require oxygen support but do not have critical illness.
We studied 196 patients admitted to 15 hospitals with moderate-to-severe pneumonia who were enrolled in two independent randomized clinical trials. We measured 42 immune mediators and markers of kidney and endothelial injury in peripheral blood within 24h of randomization in these patients.
Out of 42 parameters, age at randomization and 14 biological variables (including 11 proteins) were independently associated with the risk of death within 90 days (p<0.05, 17 with p<0.15). We constructed a generalized linear CORIMUNO model combining serum levels of KIM-1, LCN2, IL-10, and age at hospital admission that showed high discrimination for mortality (derivation cohort: area under the receiver operating characteristic curve: AUC=0.82, 95%CI: 0.73 - 0.92; validation cohort: AUC = 0.83, 95%CI: 0.74 - 0.92). Early rise in circulating kidney injury markers, in the absence of acute kidney injury criteria, was markedly associated with the risk of developing a severe form of COVID-19 and death within three months. Strikingly, even moderate COVID-19 pneumonia with normal eGFR on admission appeared strongly associated with COVID-19 kidney tubular disease. The CORIMUNO-score still achieved discrimination between the high-risk and low-risk of death groups, even in patients with normal estimated glomerular filtration (eGFR) on admission.
The CORIMUNO score identifies, for the first time, the overlooked impact of subclinical kidney injury on pneumonia outcomes and may be a helpful tool for risk stratification. It is remarkable that the strong association of kidney-derived proteins with poor outcomes and mortality supports the notion that the kidney is an overlooked sentinel organ in SARS-CoV-2 pneumonia that should be considered in future studies of patients with apparently moderate forms of sepsis. Likewise, the higher levels of the classically anti-inflammatory cytokine IL-10 in people at high risk of death is another original, little explored paradox.
