LEARNING FROM LEAKS: INSIGHTS FROM A CASE SERIES ON OUTFLOW DYSFUNCTION IN CAPD

 

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LEARNING FROM LEAKS: INSIGHTS FROM A CASE SERIES ON OUTFLOW DYSFUNCTION IN CAPD

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Prashanth
Nateshan Murthy
Prashanth Nateshan Murthy pnprashanth344@gmail.com Medway hospitals Nephrology Chennai India *
Rajeevalochana Parthasarathy jeevssri@gmail.com Medway hospitals Nephrolgy Chennai India -
Veenaa Manjari veenaa3218@gmail.com Medway hospitals Surgical gastroenterolgy Chennai India -
Sriram P pnprashanth344@gmail.com Medway hospitals Nephrology Chennai India -
Hemnath Krishnamurthy pnprashanth344@gmail.com Medway hospitals Nephrology Chennai India -
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Peritoneal Dialysate leak represents a major noninfectious complication of peritoneal dialysis (PD) forming one of the important causes of outflow dysfunction. Leaks can be classified as internal and external leaks. External leak or exit-site leak refers to the appearance of any moisture around the PD catheter identified as dialysate. Internal leaks can be into the abdominal wall, into the genital region presenting as hernias or into the pleural cavity as hydrothorax and also retroperitoneal leaks. Peritoneal dialysate leaks are one of the important causes of outflow dysfunction with limited literature available.

Retrospective chart based analysis of CAPD patients with leaks from 2022 to 2025 was done. Patient demographics, catheter insertion technique, clinical features, diagnosis and management of  leaks was documented. Internal leaks were diagnosed by clinical examination and CT abdomen with intraperitoneal contrast. Our protocol for diagnosing internal leaks involves instilling 100 ml of visipaqueTM Iodixanol contrast in 2L of peritoneal fluid. A 0 hour CT is taken and then at 1st , 3rd and 4 th hour after mobilizing the patient till the leak is evident. Exit-site and tunnel leaks were identified on inspection and ultrasound.

A total of 7 patients were included with a mean age of 65 years and male:female ratio of 3:4 . Only 3 out of the 7 had a normal BMI while the others were either overweight or obese. Five out of the 7 had internal leaks, 1 had exit site leak and one had combined exit site and pleural leak. . Laparoscopic insertion of PD catheter was done in 4 patients while the rest underwent open surgical method. Early leaks(<1 month) were seen in two patients while the majority had late leaks. Management modalities of the leaks included entry site re-fixation in one patient, deep cuff reinforcement in another, while two other patients had to be shifted to APD. After appropriate treatment PD was restarted in 5 of the patients while 2 had to be transferred to hemodialysis.(Table 1)

Characteristics and management of leaks in CAPD patients

Laparoscopic port site leak

Exit site leak and pleural leak

Subcutaneous leak


Our case series illustrates the importance of timely diagnosis and treatment of PD leaks and also the factors responsible for the leaks. Diagnosis of PD leaks needs a high degree of suspicion. Computed tomography with Intraperitoneal contrast is a valuable tool for diagnosing internal leaks. Obesity, female gender and low muscle mass are risk factors for PD leaks. With appropriate management, PD can be continued with diligent alterations in the prescription to prevent further recurrences while at the same time achieving good clearance and maintaining quality of life.

Kewords