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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Adults receiving maintenance hemodialysis (HD) frequently report pain. The HOPE Consortium Trial demonstrated an overall benefit of Pain Coping Skills Training (PCST), a cognitive behavioral therapy-based approach, on pain interference among HD patients. In this analysis we aimed to 1) evaluate whether there was heterogeneity in response to the PCST intervention; and b) identify sociodemographic, clinical, psychological, and behavioral characteristics that modified the response to PCST.
Adults with moderate to severe chronic pain receiving maintenance HD enrolled in the multicenter HOPE Consortium Trial who were randomized to receive PCST were included in this analysis. Causal forest was used to evaluate heterogeneity of treatment effect on pain interference (primary outcome) measured by the Brief Pain Inventory Interference subscale (range 0-10; higher score indicates more pain interference) at 12 weeks. Secondary outcomes included other patient-reported outcomes (pain severity, pain catastrophizing, depression, anxiety, fatigue, quality of life) at 12 weeks. Baseline demographics, comorbidities, medications, social risk factors, and psychosocial symptoms were included as covariates.
Among the 319 HOPE trial participants randomized to the PCST group (age 60.3 years, 48% women, 50% Blacks, 19% Hispanics), the causal forest average treatment effect estimate for pain interference at 12 weeks was -0.52 (95% CI -0.88 to -0.17). Heterogeneity of conditional average treatment effects was observed (minimum to maximum: -1.0 to 0.19), although it was not statistically significant (p=0.61). Participants with higher levels of depression, moderate levels of pain catastrophizing, higher levels of anxiety, and lower body mass index at baseline had greater improvement in pain interference in response to PCST training. Participants living in areas with a moderate level of socio-economic disadvantage, as measured by the area deprivation index, were more responsive to PCST than those living in areas of low or high socioeconomic disadvantage. There were no statistically significant heterogeneity of treatment effects for the secondary patient-reported outcomes of pain severity, pain catastrophizing, depression, anxiety, fatigue, or quality of life scores (p=0.41-0.99). Additional key drivers of treatment effect heterogeneity for secondary outcomes were varied and included social support, fatigue, pain severity, age and dialysis vintage.
Among patients with chronic pain undergoing maintenance HD, there were no discernible differences in response to a cognitive behavioral therapy-based pain treatment intervention based on patients’ sociodemographic, clinical, and psychological characteristics. Elevated levels of other symptoms, including depression and anxiety, demonstrated a small but significantly increased effect of the treatment in improving pain interference outcome.
