A WORLD OF DATA TO ADVANCE KIDNEY CARE: APOLLODIALDB 2.0

 

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A WORLD OF DATA TO ADVANCE KIDNEY CARE: APOLLODIALDB 2.0

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Yue
Jiao
Yue Jiao Yue.Jiao@rriny.com Renal Research Institute, LLC Advanced Analytics & Innovations New York United States *
Melanie Wolf melanie.wolf@rriny.com Renal Research Institute, LLC Advanced Analytics & Innovations New York United States -
Kaitlyn Croft kaitlyn.croft@rriny.com Renal Research Institute, LLC Advanced Analytics & Innovations New York United States -
Justin Zimbelman Justin.Zimbelman@rriny.com Renal Research Institute, LLC Advanced Analytics & Innovations New York United States -
Kanti Singh Kanti.Singh@freseniusmedicalcare.com Fresenius Medical Care IT Solutions Waltham United States -
Milind Nikam milind.nikam@freseniusmedicalcare.com Fresenius Medical Care Global Medical Office Dubai United Arab Emirates -
Adrian Guinsburg adrian.guinsburg@freseniusmedicalcare.com Fresenius Medical Care Global Medical Office Madrid Spain -
Stefano Stuard stefano.stuard@freseniusmedicalcare.com Fresenius Medical Care Global Medical Office Bad Homburg Germany -
Dinesh Chatoth Dinesh.Chatoth@freseniusmedicalcare.com Fresenius Medical Care Global Medical Office Waltham United States -
Michelle Carver Michelle.Carver1@freseniusmedicalcare.com Fresenius Medical Care Care Delivery Waltham United States -
Armin Heber armin.heber@freseniusmedicalcare.com Fresenius Medical Care Care Enablement Bad Homburg Germany -
Jacqui Nevils jacqueline.nevils@freseniusmedicalcare.com Fresenius Medical Care IT Solutions Waltham United States -
Len Usvyat Len.Usvyat@rriny.com Renal Research Institute, LLC Advanced Analytics & Innovations New York United States -
Franklin Maddux Frank.Maddux@freseniusmedicalcare.com Fresenius Medical Care AG Global Medical Office Bad Homburg Germany -
John Larkin John.Larkin@rriny.com Renal Research Institute, LLC Advanced Analytics & Innovations New York United States -

Chronic kidney disease (CKD) care is commonly supported using electronically clinical systems, producing large amounts of data over time in local settings. This real-world data has the potential to be aggregated and used outside local settings for various research purposes, such as characterizing practice patterns, understanding pathophysiology, emulating trials, and informing care models. ApolloDialDb™ initiative governs a multinational dialysis database of a global kidney care provider (Wolf M, 2025, KI Reports). It combines and harmonizes real-world data across 6 continents to create a research ready database. ApolloDialDb contains anonymized data maintained in a cloud environment, whereby data can be securely accessed throughout the world. The second version of ApolloDialDb v2.0 has been recently created. We have detailed the patient characteristics for the new dataset including clinical information on CKD care from 41 countries.

ApolloDialDb initiative captures longitudinal real-world data on an observation-level (treatment, lab, value) from a global kidney provider network (Fresenius Medical Care, Bad Homburg, DE) that uses multiple electronic clinical systems. Data is harmonized and anonymized locally and then consolidated and stored in a central cloud environment (Amazon Web Services, Seattle, USA). ApolloDialDb v2.0 captured data on more than 1000 variables from 01 Jan 2018 to 31 Dec 2024. Variables included data on demographics, diagnoses, laboratories, medications, assessments, dialysis treatments (e.g., hemodialysis, hemodiafiltration, peritoneal dialysis therapies), intradialytic measures, quality of life surveys, and outcomes.

ApolloDialDb v2.0 includes data on 852,637 adult (age ≥18 years) dialysis patients from 41 countries. The database includes information on 50,101 patients from Asia-Pacific (APAC), 113,415 patients from Europe, the Middle East and Africa (EMEA), 94,223 patients from Latin America (LatAm), and 594,898 patients from North America (NorAm) (Figure 1).Distribution of demographics showed some regional distinctions by world region. The age of patients at the progression to kidney failure and initiation of dialysis was most commonly 45-64 years old in APAC, EMEA, LatAm, and NorAm (Table 1). Despite this, there was a higher proportion of 18-44 year old patients in APAC and LatAm versus EMEA and NorAm respectively, and vice versa was observed for older patients ≥75 years old. About 40% of patients were female across world regions. Race varied by region, with high missingness in APAC and EMEA, and most patients being classified into “Other” race category in LatAm which characterizes mix and indigenous racial groups.

The research ready dialysis database ApolloDialDb v2.0 offers a view into more than 850,000 CKD patients treated by dialysis across 41 countries. It includes longitudinal data from three times more fields than the initial version of the database (Wolf M, 2025, KI Reports). Patient characteristics show that the demographics of patients vary by world region. These profiles act as benchmarks for the nephrology community.

Kewords