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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Although glomerular pathology is a defining feature of diabetic nephropathy (DN), tubular alterations, particularly proximal tubular hypertrophy, have been increasingly recognized as contributors to disease progression. This study aimed to determine whether proximal tubular hypertrophy is independently associated with adverse kidney outcomes in overt DN.
We conducted a retrospective analysis of 75 patients with biopsy-confirmed overt DN. Proximal tubular diameter was quantified morphometrically from cortical biopsy specimens. The primary outcome was a composite of ≥50% decline in estimated glomerular filtration rate (eGFR) or initiation of kidney replacement therapy (KRT). Kaplan–Meier survival analysis and multivariable Cox proportional hazards modeling were used to assess outcome associations. Covariates included age, sex, baseline CKD stage, proteinuria, and CKD stage.
The study cohort had a median age of 55 years, 83% were male, and baseline eGFR was 40 mL/min/1.73m². Over a median follow-up of 1.9 years, 52 patients reached the composite outcome. Larger proximal tubular diameter was significantly associated with poorer kidney survival (log-rank P < 0.01) (Figure). Importantly, this association remained statistically significant even after adjustment for key clinical factors including proteinuria and baseline CKD stage (adjusted HR per 1 µm increase: 1.08; 95% CI: 1.004–1.17; P = 0.04).
Proximal tubular hypertrophy is an independent predictor of kidney function decline in overt DN, beyond the effects of proteinuria and baseline eGFR. These findings highlight the underappreciated prognostic significance of tubular remodeling in diabetic kidney disease and support its inclusion in biopsy-based risk stratification.
