FEMALE DONORS, MALE RECIPIENTS: A 20-YEAR ANALYSIS OF GENDER INEQUITY IN LIVING KIDNEY DONATION

 

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https://storage.unitedwebnetwork.com/files/1099/c0bbe0c8aad3e6ccbbd95c41484eb70d.pdf
FEMALE DONORS, MALE RECIPIENTS: A 20-YEAR ANALYSIS OF GENDER INEQUITY IN LIVING KIDNEY DONATION

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Joaquim
Milheiro
Joaquim Milheiro milheiro.joaquim@gmail.com ULS Viseu Dão-Lafões Nephrology Viseu Portugal * ULS Santo António Nephrology and Kidney Transplantation Porto Portugal
Beatriz Bessa beatrizbessa@outlook.com Gaia e Espinho Nephrology Vila Nova de Gaia Portugal - ULS Santo António Nephrology and Kidney Transplantation Porto Portugal
Beatriz Pereira beatrizpereira@live.com.pt ULS Trás-os-Montes e Alto Douro Nephrology Vila Real Portugal - ULS Santo António Nephrology and Kidney Transplantation Porto Portugal
José Soares jgps88@gmail.com ULS Algarve Nephrology Faro Portugal - ULS Santo António Nephrology and Kidney Transplantation Porto Portugal
Sandra Pereira sandrapereira.nefrologia@ulssa.min-saude.pt ULS Santo António Nephrology and Kidney Transplantation Porto Portugal -
João Fernandes joaofernandes.nefrologia@ulssa.min-saude.pt ULS Santo António Nephrology and Kidney Transplantation Porto Portugal -
Catarina Ribeiro catarina.ribeiro.nefrologia@ulssa.min-saude.pt ULS Santo António Nephrology and Kidney Transplantation Porto Portugal -
José Silvano jose.silvano.nefrologia@ulssa.min-saude.pt ULS Santo António Nephrology and Kidney Transplantation Porto Portugal -
Sofia Pedroso sofiapedroso.nefrologia@ulssa.min-saude.pt ULS Santo António Nephrology and Kidney Transplantation Porto Portugal -
Manuela Almeida manuela.almeida10@gmail.com ULS Santo António Nephrology and Kidney Transplantation Porto Portugal -
La Salete Martins lasaletemartins.nefrologia@ulssa.min-saude.pt ULS Santo António Nephrology and Kidney Transplantation Porto Portugal -
 
 
 
 

Gender disparities in living kidney donation remain a major challenge, with women disproportionately serving as donors and men more often as recipients. Evidence on how donor–recipient sex combinations affect outcomes is limited. We aimed to assess the impact of gender on the access to and outcomes of living kidney transplantation at our center. 

We retrospectively analyzed all living donor kidney transplantations performed at a Portuguese center between 1998 and 2019 (n=365). Donor and recipient demographics, pre-emptive transplantation rates, graft survival, and acute rejection episodes were compared according to gender and donor–recipient sex combinations using non-parametric tests. Multivariate models were applied to adjust for age and clinical covariates. 

Women represented 69% of donors, whereas 65% of recipients were men. Pre-emptive transplantation was more common in male recipients (21.9% vs 13.5%; p <0.037). Five-year graft survival did not differ between male-to-male and male-to-female transplants (93,8% vs 92,7%; p = 0.897). At 5 years, a higher risk of acute rejection was not demonstrated in any donor-recipient sex combination. Recipient gender remained an independent predictor of outcomes after age adjustment (p <0.05). 

Living kidney donation at our center demonstrates persistent gender inequity, with women contributing most donors and men most recipients. Male recipients accessed pre-emptive transplantation at significantly higher rates, revealing systematic barriers to optimal care for female patients. Despite these access disparities, graft survival outcomes were excellent and comparable across donor-recipient sex combinations. These findings underscore the need for healthcare policy reforms to ensure equitable access to living donor transplantation and pre-emptive care, while further research should elucidate the mechanisms by which recipient sex influences long-term outcomes.

Kewords