CHANGE IN DEMOGRAPHICS OF KIDNEY DONORS AND THEIR RELATIONSHIP TO RECIPIENTS OVER THE PAST TWELVE YEARS IN NEPAL.

 

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https://storage.unitedwebnetwork.com/files/1099/a9183964db6a0823fb1350ebf2b011c1.pdf
CHANGE IN DEMOGRAPHICS OF KIDNEY DONORS AND THEIR RELATIONSHIP TO RECIPIENTS OVER THE PAST TWELVE YEARS IN NEPAL.

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Chahana
Bogati
Chahana Bogati cbogati@gmail.com Shahid Dharmabhakta National Transplant Centre Nursing and Research Bhaktapur Nepal *
Dipesh Shrestha itsmedipesh66@gmail.com Shahid Dharmabhakta National Transplant Centre Urology and Renal Transplant Bhaktapur Nepal -
Kalpana Kumari Shrestha drkalpanashrestha@gmail.com Shahid Dharmabhakta National Transplant Centre Nephrology Bhaktapur Nepal -
Pratima Nyaupane pratima.neupane.np@gmail.com Shahid Dharmabhakta National Transplant Centre Microbiology Bhaktapur Nepal -
Lushan Singh singhlushan@gmail.com Shahid Dharmabhakta National Transplant Centre Nephrology Bhaktapur Nepal -
Dipendra Kandel dipendrakandel5000@gmail.com Shahid Dharmabhakta National Transplant Centre Medical Officer and Research Bhaktapur Nepal -
Sugat Ratna Tuladhar rectifieratcbeas@gmail.com Shahid Dharmabhakta National Transplant Centre Biomedical Engineering and Research Bhaktapur Nepal -
Pukar Chandra Shrestha pcshrestha@yahoo.co.uk Shahid Dharmabhakta National Transplant Centre Renal and Liver Transplant Department Bhaktapur Nepal -
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The treatment of choice for end-stage kidney disease (ESKD) is kidney transplantation, which offers better quality of life and survival than dialysis. Almost all kidney transplants in Nepal rely on  living donors due to unavailiabilty of cadaveric donors. Although Legislative changes including amendment in Human Body Transplantation Act, Nepal in 2016 expanded the potential donor pool to 51 close relatives and has also included paired exchange yet the dependency on living donation calls for a rigorous examination of changing donor-recipient dynamics. This study sought to identify changing trends in living kidney donation in Nepal by assessing changes in donor-recipient relationships and demographic factors over a 12-year period.

A retrospective observational study was conducted at Shahid Dharmabhakta National Transplant Center, Bhaktapur, Nepal, to determine the demographic characteristics and donor-recipient relationships in living kidney transplants performed from 2013 AD to 2025 AD. Donor-recipient relationships were classified as first-degree relatives (parents, siblings, children), second-degree relatives (uncles, aunts, cousins), spouses, or unrelated donors. IBM SPSS Statistics version 23.0 was used to analyse the data. Chi-square and linear-by-linear association tests were used to compare categorical variables over four time periods (2013–2015, 2016–2018, 2019–2021, 2022–2024). Statistical significance was defined as a p-value <0.05.

Among 1332 study population, the mean age of the recipients was 36.2 ± 10.9 years, with  majority ,79.4% being male. On the other hand the majority of donors (72.3%) were female, and the average age of donors was 44.9 ± 11.8 years. Of the donors, 52.3% were first-degree relatives to their recipients, followed by wives to husband (31.8%), husbands to wives (5.3%), and  from second-degree relatives (4.7%). Over a 12-year period, the percentage of first-degree donors fell from 65% (2013–2015) to 47.6% (2022–2024), but the percentage of second-degree donors rose from 2.4% to 6% and the percentage of biologically unrelated donors rose from 3.3% to 7.6% (p=0.029). 

The donor relationships and demographics in Nepal's living kidney transplantation program have changed significantly over the past 12 years. The majority of donors are still first-degree relatives, although older persons, spouses, and those who are not biologically related are also becoming more and more involved. These changes might be a result of changing family relations, progressive laws, and heightened public awareness. Maintaining safe and equitable kidney transplantation procedures in Nepal requires ongoing focus on donor safety, ethical supervision, and the concurrent development of brain dead donor programs.

Kewords