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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Activation of the complement system is now recognized as a key contributor to the progression of IgA nephropathy (IgAN). Among the complement pathways, accumulating evidence supports the involvement of the alternative pathway. However, the clinical implications of complement activation, including treatment response, have not yet been fully elucidated. We investigated the clinical impact of complement activation status in patients with biopsy proven IgAN.
This study included 50 patients with biopsy-proven IgAN. Patients were divided into two groups based on their C3 deposition intensity. We conducted a retrospective analysis of the role of complement in the glomerulus in the clinical and pathological features, including Oxford classification and treatment responses, in these two groups. Furthermore, we investigated the association between circulating complement levels and therapeutic responsiveness.
A total of 41 patients and 9 patients were classified as C3 positive and C3 negative, respectively. Although no significant increase was observed in indicators of active inflammation, such as the severity of hematuria or the C score, patients with glomerular C3 deposition were more likely to present with a positive S score in this cohort (P=0.02). No significant difference was observed in remission rates between the two groups following tonsillectomy and steroid pulse therapy (TSP). Our results also showed that neither the serum C3 levels at the time of kidney biopsy nor their subsequent changes were significantly associated with remission after TSP.
C3 deposition may play a pivotal role in the progression of chronic renal lesions in patients with IgAN, potentially by promoting sustained inflammatory responses. Although previous studies have reported that C3 deposition or decreased serum C3 levels are associated with poor prognosis, the remission rate did not differ between patients with IgAN who underwent TSP, regardless of the presence of glomerular C3 deposition or low serum C3 levels. Nevertheless, these findings should be validated in studies with larger patient cohorts.
