PREDICTIVE MODEL FOR UNPLANNED DIALYSIS INITIATION IN STAGE 5 CKD PATIENTS: RESULTS FROM THE TRADITCO STUDY

 

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https://storage.unitedwebnetwork.com/files/1099/bfb8419eeb28cc075eb8abd0e90bfb83.pdf
PREDICTIVE MODEL FOR UNPLANNED DIALYSIS INITIATION IN STAGE 5 CKD PATIENTS: RESULTS FROM THE TRADITCO STUDY

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Peter
Rutherford
Peter Rutherford peter.rutherford@vantive.com Vantive corporation Medical Affairs Zurich Switzerland *
Mauricio Sanabria mauricio.sanabria@vantive.com Renal Care Services Latin-America Medical Affairs Bogota Colombia -
Jasmin Vesga jasmin.vesga@vantive.com Renal Care Services Colombia Medical Affairs Bucaramanga Colombia -
Sergio Paez spaezm@unal.edu.co National University of Colombia Science Bogota Colombia -
Angela Rivera angela.rivera@vantive.com Vantive corporation Medical Affairs Deerfield United States -
 
 
 
 
 
 
 
 
 
 

Unplanned initiation of dialysis is associated with increased short-term negative outcomes and healthcare costs. Early identification of at-risk patients allows proactive care and a smoother transition to kidney replacement therapy (KRT). This study aimed to develop and validate a predictive model for unplanned dialysis initiation among stage 5 CKD patients in a nephroprotection program.

A retrospective cohort analysis included 1,471 patients with CKD stage G5 enrolled in the Renal Care Services (RCS) nephroprotection program in Colombia. Data were randomly split into a 70% training set and a 30% internal validation set. A logistic regression model was developed using LASSO for variable selection and Ridge penalization to stabilize coefficients. Model performance was evaluated by the area under the ROC curve (AUC) and the confusion matrix.

We observed unplanned dialysis initiation in 35.5% of cases (n = 522). The predictive model included the following factors: having permanent access, serum albumin levels, the use of angiotensin II receptor blockers, the Karnofsky scale score, absenteeism, and the number of emergency visits or hospitalizations. The permanent access variable has the greatest weighting in the model (Table 1). Model performance was excellent; the sensitivity was 0.81, with a specificity of 0.99, and the area under the ROC curve was 0.94 (Table 2). Figure 1 provides an overview of the proposed tool for clinicians in the CKD program.

Table 1. Predictive model for unplanned dialysis initiation


Table 2. Metrics for the confusion matrix


The TRADITCO predictive model has a high level of accuracy in identifying cases of unplanned dialysis initiation. Integrating this tool into clinical practice could support real-time risk stratification, enabling earlier multidisciplinary interventions and improved outcomes.

Kewords