COLOMBIAN REGISTRY OF GLOMERULAR DISEASES (REGLOCOL)

 

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COLOMBIAN REGISTRY OF GLOMERULAR DISEASES (REGLOCOL)

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Gustavo
Aroca-Martínez
Gustavo Aroca-Martínez garoca1@clinicadelacosta.co Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF) Atlántico Barranquilla Colombia *
Christian Figueroa-Millán figueroa.christian@outlook.com Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF) Antioquia Medellín Colombia -
Jose Lucas Daza drlucasdaza@gmail.com Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF) Ibague Tolima Colombia -
Andres Cadena Bonfanti acadena@clinicadelacosta.co Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF) Atlántico Barranquilla Colombia -
Valentina Pérez-Jiménez dra.valentina.perez.jimenez@gmail.com Universidad Simón Bolívar Atlántico Barranquilla Colombia -
Karen Lasso-Latorre karenlasso_1618@hotmail.com Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF). Nariño Pasto Colombia -
Jaime Torres-Saltarín jjtorressantarin@gmail.com Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF). Tolima Ibagué Colombia -
Eduardo Puche-Carrascal dr.epuchenefro@hotmail.com Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF). Córdoba Montería Colombia -
Roberto Ramírez robertoramirez550@gmail.com Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF). Valle del cauca Cali Colombia -
Rafael Pérez Padilla jyrperez202017@gmail.com Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF). Antioquia Medellín Colombia -
Liliana Rodriguez lilorg86@hotmail.com Asociación Colombiana de Nefrología e Hipertensión (ASOCOLNEF). Meta Villavicencio Colombia -
María Arcoa-Vidal mp.arocav2@gmail.com Clínica de la Costa, Barranquilla, Colombia. Atlántico Barranquilla Colombia -
Nicoll Fontalvo-Avila nicollfun@gmail.com Clínica de la Costa, Barranquilla, Colombia. Atlántico Barranquilla Colombia -
Kanery Camargo-Rodriguez kanery111104@gmail.com Clínica de la Costa, Barranquilla, Colombia. Atlántico Barranquilla Colombia -
Esteban Vásquez-Obeso itclinica@clinicadelacosta.co Clínica de la Costa, Barranquilla, Colombia. Atlantico Barranquilla Colombia -

Glomerular diseases are significant causes of chronic kidney disease (CKD) and are categorized as either primary or secondary. FSGS, IgA nephropathy, and membranous nephropathy are the most common primary forms, while lupus nephritis predominates among secondary causes. The REGLOCOL registry seeks to define their epidemiology and clinical profile in Colombia.

REGLOCOL is a multicenter observational study with both prospective and retrospective components, enrolling adults (≥18 years) with biopsy-confirmed glomerulopathies diagnosed between 2010 and 2025. Approved by the ethics committees of the participating institutions, the registry collects clinical, histopathological, and therapeutic data through an electronic platform equipped with automated validation systems. The registry includes variables across five domains: sociodemographic data, laboratory findings, histopathology, treatment, and comorbidities. As of October 9, 2025, 864 patients had been enrolled for preliminary descriptive analysis.

The prospective registry is expanding, increasing statistical power and enabling detailed analyses. Among 864 biopsy-confirmed cases, 70.7% were primary glomerulopathies. Lupus nephritis (22.8%) and focal segmental glomerulosclerosis (22.1%) were most frequent, followed by membranoproliferative glomerulonephritis (14.1%) and IgA nephropathy (12.0%).

Lupus nephritis predominated in young adults, while focal segmental glomerulosclerosis and membranous nephropathy were more common in older individuals. Most patients were women (56.8%), of mixed ethnicity (55.6%), and from middle socioeconomic strata (49.3%).

High rates of hypertension (35.3%) and nephrotic syndrome (39.8%) underscore the need for early detection and integrated management. Preliminary findings offer valuable insights into the epidemiology of glomerular diseases in Colombia.



REGLOCOL is the first national multicenter initiative to systematically characterize glomerular diseases in Colombia. Preliminary data show a distribution comparable to other Latin American countries, with regional variations reflecting the nation’s epidemiological diversity. Primary glomerulopathies represented 70.7% of cases and secondary 29.3%, with lupus nephritis and focal segmental glomerulosclerosis being the most common. The predominance of young women and the high burden of autoimmune diseases highlight the need for early diagnosis and continuous monitoring. REGLOCOL stands as a crucial platform for research and epidemiological surveillance, with the potential to guide public health policies and strategies to reduce the burden of kidney disease in Colombia.

Kewords