Back
For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".
To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".
During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Change in proteinuria and the eGFR slope are known to be predictive markers for the progression of chronic kidney disease (CKD). However, the utility and associated factors of eGFR slope and changes in proteinuria remain unclear in patients particularly without diabetes. In this study, we evaluated the relationship of eGFR slope and change in proteinuria with subsequent clinical outcomes and their associated factors in patients with CKD.
We used data from the FROM-J study, which was a cluster-randomized controlled study to evaluate the effectiveness of a CKD clinical facilitation program.
We calculated the annual eGFR change over 2 years and proteinuria change over 1-year. We assessed the association of these markers with renal replacement therapy (RRT) initiation, cardiovascular disease (CVD) events, and death using Cox proportional hazards model adjusted for multiple risk factors including eGFR, sex and age. Subgroup analysis was performed with or without the presence of hypertension and diabetes.
Risk factors associated with long term change in proteinuria and eGFR were evaluated, using logistics regression.
This study included 2,379 patients with CKD. At baseline, the mean age was 62 years; 1,712 (72%) were male; the mean eGFR was 57.8 mL/min/1.73m²; 1,445 patients (61%) had diabetes, and 2,141 (91%) had hypertension.
During the mean follow up of 10 years, 179 and 202 patients experienced RRT initiation and CVD events and 212 patients died. Patients who experienced a >=30% reduction in proteinuria had a significantly lower risk of RRT initiation (HR 0.53; 95% CI, 0.32 to 0.89) compared to those without. Patients with an eGFR slope of >=–5 mL/min/1.73 m²/year also had a significantly lower risk of RRT initiation (HR 0.074; 95% CI, 0.05 to 0.11), CVD events (HR 0.40; 95% CI, 0.24 to 0.66), and death (HR 0.46; 95% CI, 0.26 to 0.83).
In subgroup analysis, similar associations were observed regardless of the presence of hypertension and diabetes.
Risk factors associated with eGFR faster decline included diabetes (OR 2.76 ;95% CI 1.85-4.13), and systolic blood pressure (OR 1.03 ;95% CI 1.02-1.04 per 1 mmHg) at baseline. Furthermore, risk factors associated with proteinuria reduction included support of registered dietitian (OR 1.43; 95% CI 1.01-2.02) and consult of nephrologist (OR 1.47; 95% CI 1.01-2.13) at baseline.
Slower eGFR decline and reductions in proteinuria are associated with better prognosis in patients with CKD. Risk management by multidisciplinary staffs may improve progression of CKD.
