INFECTION-RELATED GLOMERULONEPHRITIS WITH HEMOLYTIC ANEMIA AND THROMBOCYTOPENIA FOLLOWING TREATMENT FOR STREPTOCOCCAL BACTEREMIA A CASE REPORT

 

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https://storage.unitedwebnetwork.com/files/1099/c6b4ca804c1ab6def9fb0399fda43996.pdf
INFECTION-RELATED GLOMERULONEPHRITIS WITH HEMOLYTIC ANEMIA AND THROMBOCYTOPENIA FOLLOWING TREATMENT FOR STREPTOCOCCAL BACTEREMIA A CASE REPORT

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Takafumi
Shiga
Takafumi Shiga tshigahandtable@gmail.com Kagawa Rosai Hospital Department of internal medicine Marugame Japan *
Keisuke Onishi onishi.keisuke@kagawa-u.ac.jp Kagawa University Hospital Department of Cardiorenal and Cerebrovascular medicine Takamatsu Japan -
Tadashi Sofue sofue.tadashi@kagawa-u.ac.jp Kagawa University Hospital Department of Cardiorenal and Cerebrovascular medicine Takamatsu Japan -
Emi Ibuki ibuki.emi@kagawa-u.ac.jp Kagawa University Hospital Department of Molecular Oncologic Pathology, Pathology and Host Defense Takamatsu Japan -
Tetsuo Minamino minamino.tetsuo.gk@kagawa-u.ac.jp Kagawa University Hospital Department of Cardiorenal and Cerebrovascular medicine Takamatsu Japan -
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Post-streptococcal acute glomerulonephritis (PSAGN) occurs 1-3 weeks after infections of the upper respiratory tract or skin. Infection-related glomerulonephritis can be accompanied by anemia and thrombocytopenia; however, the detailed mechanism remains unknown. Here, we report a case of PSAGN complicated by hemolytic anemia and thrombocytopenia after treatment for streptococcal bacteremia.

Report a clinical case of hospital in Kagawa, Japan.

A previously healthy 64-year-old woman was admitted to our hospital with fever and abdominal pain.  The day before, she had visited a gynecologist for genital itching and was diagnosed with bacterial vaginitis due to group A Streptococcus (GAS). Laboratory data showed C-reactive protein level of 43 mg/dl and WBC 19100/µl, and blood culture revealed GAS. Although antibiotics were administered, fever and right-sided chest pain persisted. Surgical thoracic drainage was performed after a diagnosis of pyothorax based on CT and pleural fluid analysis. Postoperative fever persisted, and 14 days after admission, serum creatinine (Cr) was 1.2 mg/dL and urinalysis results were normal; however, low C3 and CH50 levels were observed. On day 21 after admission, gross hematuria developed, and urinalysis revealed proteinuria. Based on the patient’s medical history and positive ASO findings, she was clinically diagnosed with PSAGN. Progressive thrombocytopenia, hemolytic anemia, and schistocytes were also observed; the development of thrombotic microangiopathy (TMA) was suspected.

The coexistence of PSAGN with hemolytic anemia and thrombocytopenia is rare. TMA was clinically suspected in this case. While some reports describe histological findings suggestive of TMA, such as endothelial injury, these features were absent on renal biopsy in the present case. A potential mechanism involves Streptococcus infection-mediated complement activation, which may contribute to both PSAGN and the hematologic findings. Therefore, glucocorticoid therapy may represent an effective treatment option in such cases.

Kewords