WHEN TO CONSIDER KIDNEY SUPPORTIVE CARE? AN INTERNATIONAL EDELPHI CONSENSUS STUDY OF CLINICAL INDICATORS

 

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https://storage.unitedwebnetwork.com/files/1099/f87167612abd02c28d9d5a99cd852197.pdf
WHEN TO CONSIDER KIDNEY SUPPORTIVE CARE? AN INTERNATIONAL EDELPHI CONSENSUS STUDY OF CLINICAL INDICATORS

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Kathryn
Ducharlet
Kathryn Ducharlet kathryn.ducharlet@easternhealth.org.au Eastern Health Eastern Health Integrated Renal Services Melbourne Australia * Monash University Eastern Health Clinical School Box Hill Australia
David Hui dhui@mdanderson.org The University of Texas MD Anderson Cancer Centre Houston United States -
Sara Davison sdavison@ualberta.ca University of Alberta Divison of Nephrology and Immunology Alberta Canada -
Vivek Jha vjha60@gmail.com The George Institute for Global Health Public Health New Deli India -
Alvin (Woody) Moss amoss@hsc.wvu.edu West Virginia University Divisions of Nephrology, Geriatrics and Palliative Medicine Morgantown United States -
Anna Collins Anna.Collins@svha.org.au University of Melbourne Department of Medicine Fitzroy Australia -
Shao-Yi Cheng scheng2140@gmail.com National Taiwan University Department of Family Medicine Taiwan Taiwan -
Yuchieh Kathryn Chang ykchang.do@gmail.com University of Texas Department of Palliative Care, Rehabilitation and Integrative Medicine Houston United States -
Frank Brennan fpbrennan@ozemail.com St George Hospital Department of Palliative Care Sydney Australia -
Masanori Mori masanori.mori@sis.seirei.or.jp Seirei Mikatahara General Hospital Division of Palliative and Supportive Care Shizuoka Japan -
Nicki Scholes-Robertson nicole.scholes-robertson@sydney.edu.au University of Sydney School of Public Health Sydney Australia -
Nicola Wearne nicola.wearne@uct.ac.za University of Cape Town Division of Nephrology and Hypertension Cape Town South Africa -
Pedro Perez-Cruz peperez@uc.cl Catholic University of Chile Department of Palliative Medicine Santiago Chile -
Fliss Murtagh fliss.murtagh@hyms.ac.uk University of Hull Department of Palliative Care Hull United Kingdom -
Jennifer Philip jphilip@unimelb.edu.au University of Melbourne Department of Medicine Melbourne Australia -

Kidney supportive care (KSC) aims to improve the quality of life for people with advanced chronic kidney disease (CKD Stage IV and V) and the International Society of Nephrology recommends that it be an integrated part of global kidney care. However, it is unclear when clinicians should initiate KSC approaches in addition to standard kidney care. The aim of this study was to develop a global consensus of clinical indicators prompting when to consider outpatient KSC for people with advanced CKD. 

A 15-person international multidisciplinary steering committee established project objectives, parameters, and anticipated outcomes. The steering committee nominated individuals with expertise in KSC to form an expert panel of kidney and palliative care clinicians.  Panellists were invited to participate in 3 sequential eDelphi surveys via email using Qualtrix software in which, clinical and demographic information and views on clinical prompts for KSC were collected.  A consensus was defined a priori as an agreement (i.e. agree or strongly agree) by a minimum of 70% of the panellists

Between November 2024 and August 2025, 129 clinicians comprised the panel with response rate was 94% for round 1, 90% for round 2 and 95% for round 3. Participant demographics are shown in Table 1.

In the first round of the online eDelphi surveys panellists were asked, based on their experience, when they would consider implementing outpatient kidney supportive care for a person with advanced CKD using a 5-point Likert scale from 1=Strongly Agree to 5=Strongly Disagree.  The proposed clinical indicators were based on a previous systematic literature review (1) and expert steering committee input. Participants could also provide free text answers to add additional indicators and comments.  The Round 2 survey revised the clinical indicators and removed those that did not reach a consensus in Round 1. The second round asked whether clinicians would consider each factor as a major (this clinical indicator alone would be sufficient to consider KSC) or minor indicators (two or more clinical indicators would prompt KSC integration.  Round 2 also asked about the timing of the clinical indicator, if it was deemed too early, too late or the right time (Table 2).  Round 3 asked for consensus on the major indicators.  The final survey confirmed a consensus of 15 major clinical indicators across 4 domains: specific patient clinical and prognostic factors; severe physical, spiritual or emotional symptoms; assistance with clinical decision making or end of life care; and high health care utilization (Figure 1).



Table 1


Table 2


This study provided an international consensus on parameters for clinicians to consider in integrating a KSC approach into standard advanced CKD care.  Further research is required to examine the feasibility of implementing them and their implications for patient care outcomes.


Kewords