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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Accurate evaluation of kidney function in living donors prior to donation is essential. Measured glomerular filtration rate (mGFR) remains the gold standard for assessing kidney function; however, its clinical use is limited by its invasive nature, time requirements, and high costs. Symmetric dimethylarginine (SDMA) has recently emerged as a promising biomarker for the diagnosis and screening of kidney disease in small animal practice. To date, however, the relationship between SDMA and mGFR in humans has rarely been investigated. This study aims to evaluate the association between baseline plasma SDMA level and mGFR both at baseline and three months after donation in living kidney donors.
Living donor data were obtained from the prospective TransplantLines study. Assessments of mGFR were performed using I125-iothalamate at baseline and three months after donation in living kidney donors. Pre-donation and post-donation plasma SDMA and cystatin C concentrations were determined using an automated IDEXX SDMA® immunoassay and a turbidimetric assay, respectively. Univariable and multivariable linear regression analyses were performed to examine the associations between baseline kidney function indices and mGFR. Differences between regression coefficients were assessed using Steiger’s Z-test.
Plasma SDMA and mGFR data were available for 46 living donors (Table 1). Mean SDMA and cystatin C before donation were 11.2 ± 1.6 ug/dL and 0.87 ± 0.18 mg/L, respectively. Values of mGFR before donation and at 3 months after donation were 95.4 ± 13.2 ml/min/1.73m2 and 60.8 ± 8.9 ml/min/1.73m2. Pre-donation plasma SDMA was significantly associated with both pre- and post-donation mGFR (st. β: -0.51 ,95%CI [-0.76,-0.26], p<0.001 and st. β: -0.49, [-0.75,-0.23], p<0.001, respectively). Associations remained materially unchanged after multivariable adjustment for donor age, sex, BMI, smoking status, hypertension, and diabetes. Moreover, we found that the strength of the association of plasma SDMA with both pre- and post-donation mGFR was comparable to that of plasma cystatin C (both p>0.05).
These findings indicate that pre-donation plasma SDMA exhibits an association with kidney function comparable to that of cystatin C, both before and after kidney donation in living donors. SDMA may serve as a novel biomarker for assessing kidney function in living donors.
