A CROSS-SECTIONAL COMPARATIVE STUDY ON RISK FACTORS FOR KIDNEY STONE DISEASE IN A TERTIARY CARE HOSPITAL IN SOUTHERN INDIA

 

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https://storage.unitedwebnetwork.com/files/1099/02cf5a73ab99886ff853f08c49f240d7.pdf
A CROSS-SECTIONAL COMPARATIVE STUDY ON RISK FACTORS FOR KIDNEY STONE DISEASE IN A TERTIARY CARE HOSPITAL IN SOUTHERN INDIA

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Anitha
Swamy
Anitha Swamy dr.anitha.15@gmail.com All India Institute of Medical Sciences Nephrology Hyderabad India *
Syed Danish Sharief dr.sharief.syed@gmail.com All India Institute of Medical Sciences Nephrology Hyderabad India -
Satya Shree Parelli psatya62@gmail.com All India Institute of Medical Sciences Nephrology Hyderabad India -
Anand Pyati anandpyati999@gmail.com All India Institute of Medical Sciences Biochemistry Hyderabad India -
Aparna Varma aparnav9@gmail.com All India Institute of Medical Sciences Biochemistry Hyderabad India -
Gomathi R drgomath05@gmail.com All India Institute of Medical Sciences Community and Family Medicine Hyderabad India -
Raja S rajacmc87@gmail.com All India Institute of Medical Sciences Microbiology Hyderabad India -
Annapurna Srirambhatla purnasrirambhat@gmail.com All India Institute of Medical Sciences Radiodiagnosis Hyderabad India -
Radhika Soanker dr_radhika_s@yahoo.co.in All India Institute of Medical Sciences Pharmacology Hyderabad India -
Sangeetha Sampath ssampathbbnagar@gmail.com All India Institute of Medical Sciences Biochemistry Hyderabad India -
 
 
 
 
 

Kidney Stone Disease (KSD) imposes a significant economic burden due to its high prevalence and recurrence, particularly among individuals in the most productive age group 21-50 years. Several epidemiological studies also demonstrated an association between kidney stones and progression to CKD and ESKD. Hence, effective prevention and management of KSD are of great importance. We have observed a substantial number of patients presenting with KSD in our OPD from districts in and around the location of our relatively new institute in South India. Therefore, we conducted this study to identify specific risk factors for KSD among the patient population in this region. To our knowledge, this is the first study to evaluate risk factors contributing to KSD in this area.

We conducted a cross-sectional comparative study among patients aged >18 years with an eGFR >30 ml/min/1.73m2 attending the Nephrology OPD of our newly established tertiary care hospital. Patients meeting the inclusion and exclusion criteria were included. A consecutive sampling procedure was used. Newly diagnosed or recurrent KSD patients diagnosed using USG at their first presentation, were selected as cases. Age and gender matched hospital-based controls were recruited for comparison. Detailed histories were obtained, and risk factors for KSD, including demographic, lifestyle, metabolic, and environmental factors, were assessed. Metabolic evaluation included detailed blood investigations, 24-hour urine analysis, and drinking water analysis for all participants. A total of 62 KSD cases and 52 age and gender matched controls were recruited after screening 150 potential cases and 68 potential controls. 65% of the cases were recurrent stone formers, and 31.7% had a family history of KSD among first degree relatives.

Baseline Characteristics of Cases and ControlsTable 2: Comparison of Blood Investigations Between the Two GroupsComparison of 24-Hour Urinary Parameters Between the Two GroupsThe baseline characteristics of the study participants are shown in Table 1. Drinking status, socioeconomic status, and a positive family history differed significantly between the case and control groups. Blood investigations were comparable between the two groups (Table 2). The 24-hour urinary citrate excretion was significantly lower among the cases (260.4 mg/day vs. 497.3 mg/day; p=0.001) (Table 3). Drinking water calcium (17.36 mg/L vs 13.2 mg/L; p =0.03) and nitrate levels were significantly higher among the cases (19.9 mg/L vs 14.6 mg/L; p =0.01) (Table 4).

Kidney stone disease was associated with lower urinary citrate levels, higher calcium and nitrate levels in drinking water, and alcohol consumption in this study population. Identifying and addressing these modifiable factors may help reduce the disease burden.

Kewords