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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Chronic Kidney Disease (CKD) is a state of chronic persistent low grade systemic inflammation, increased catabolism, decreased appetite, and poor nutritional intake which together create a complex metabolic state - the MIA syndrome. Patients with CKD have an elevated cardiovascular risk manifesting as coronary artery disease, heart failure, arrhythmias, or sudden cardiac death. Left ventricle hypertrophy and subsequent diastolic dysfunction is considered to be one of the pathological hallmarks in CKD and is associated with greater progression and higher mortality. We aimed to evaluate the various components of MIA Syndrome and associated risk of left ventricular diastolic dysfunction (LVDD).
We performed a prospective study between January 2021 and July 2022. 207 patients were enrolled in this study. Individual components of MIA were defined as malnutrition, if serum albumin< 3.5g/dl, inflammation if CRP >10ng/dl, and atherosclerosis, if carotid intimal thickness > 1 mm. Standard echocardiographic criteria were used to determine patients with isolated LVDD. We developed linear and logistic regression models to determine the relationship between individual components of the MIA syndrome and the risk of LVDD.
Out of 207 patients, 148/207(71.5%) were males and 59/207(28.5%) were females. Mean age for males was 50.6 ±13.62 years and females was 54.3 ± 12.38) years. Malnutrition was present in 185/207 (89.4%), inflammation in 171/207 (86.6%) and atherosclerosis in 58/207 (28.0%). All the 3 components were present in 57/207 (27.5%). There was a small but significant inverse and independent correlation between CRP and albumin (correlation coefficient - 0.004, p value < 0.001), however the strength of this model was poor (R square = 0.08). There was a significant strong independent association between atherosclerosis and serum albumin (odds ratio = 0.31, p value = 0.007). The independent association between atherosclerosis and CRP was significant (odds ratio = 1.2, p value = 0.002). Patients with all three components of the MIA syndrome were also found to have an independent increased risk risk of LVDD (odds ratio = 2.2, p value = 0.01).
Our results show that there is an interconnection between the three components of the MIA syndrome and this plays a significant role in increasing the risk of LVDD. Future therapies aimed at reversing this complex metabolic conundrum could be a crucial milestone for CKD patients.
