INFECTION-RELATED GLOMERULONEPHRITIS OUTCOMES IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS (INGOD) STUDY - International Society of Nephrology Events

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E-Poster

Abstract Title *

INFECTION-RELATED GLOMERULONEPHRITIS OUTCOMES IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS (INGOD) STUDY

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Presenter First Name

Vamsidhar

Presenter Surname

Veeranki

Co-author 1

Vamsidhar Veeranki vamsidharveeranki@gmail.com Medanta Global health Limited Nephrology Lucknow India *

Co-author 2

Narayan Prasad narayan.nephro@gmail.com Sanjay Gandhi Postgraduate Institute of Medical Sciences Nephrology Lucknow India -

Co-author 3

Jeyakumar Meyyappan jeyakumarmeyyappan@gmail.com Sanjay Gandhi Postgraduate Institute of Medical Sciences Nephrology Lucknow India -

Co-author 4

Dharmendra singh Bhadauria docdharm10@gmail.com Medanta Global health Limited Nephrology Lucknow India -

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Introduction

Infection-related glomerulonephritis (IRGN), historically linked to streptococcal infections, has evolved in its clinical presentation and spectrum over centuries. Recent decades have seen an increased prevalence of IRGN in adults, particularly those with comorbidities like diabetes mellitus (DM), which may negatively impact renal outcomes. This study compares clinical profiles and short- and long-term renal outcomes of biopsy-confirmed IRGN in diabetic and non-diabetic patients.

Methods

A retrospective observational study was conducted from January 2010 to December 2023 at a single center, including patients ≥18 years with biopsy-confirmed IRGN. Patients with IRGN were categorized into two cohorts: with and without DM. Baseline demographics, clinical characteristics, and outcomes were analyzed and compared between these groups. Statistical tests, including Kaplan-Meier and Cox regression analyses, were used to evaluate survival outcomes and predictive factors for non-responsiveness.

Results

Among 117 patients, 38 were diabetic, and 79 were non-diabetic. Short-term remission rates were significantly lower in diabetics (57.8% vs. 93.7%, p<0.001), and long-term renal survival at 48 months was also inferior (44.7% vs. 96.3%, p<0.001). Propensity score matching confirmed that diabetics had poorer outcomes even when adjusted for age, IFTA, and glomerular basement membrane (GBM) thickening. Multivariate analysis identified DM as a strong predictor of poor renal recovery (adjusted OR: 15.04, p<0.001).

Conclusion

Among 117 patients, 38 were diabetic, and 79 were non-diabetic. Short-term remission rates were significantly lower in diabetics (57.8% vs. 93.7%, p<0.001), and long-term renal survival at 48 months was also inferior (44.7% vs. 96.3%, p<0.001). Propensity score matching confirmed that diabetics had poorer outcomes even when adjusted for age, IFTA, and glomerular basement membrane (GBM) thickening. Multivariate analysis identified DM as a strong predictor of poor renal recovery (adjusted OR: 15.04, p<0.001).

Kewords