COMPARATIVE OUTCOMES OF ARTERIOVENOUS FISTULAS AND CENTRAL VENOUS CATHETERS IN HOME HEMODIALYSIS PATIENTS: A MULTICENTER, LONGITUDINAL COHORT STUDY

 

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COMPARATIVE OUTCOMES OF ARTERIOVENOUS FISTULAS AND CENTRAL VENOUS CATHETERS IN HOME HEMODIALYSIS PATIENTS: A MULTICENTER, LONGITUDINAL COHORT STUDY

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Ni Made
Hustrini
Ni Made Hustrini madekum99@gmail.com Universitas Indonesia & Leiden University Medical Center Internal Medicine Jakarta Indonesia *
Emiel W.G de Bruin e.w.g.debruin@students.uu.nl University Medical Center Utrecht Nephrology and Hypertension Utrecht Netherlands -
Esmee Driehuis e.driehuis@amsterdamumc.nl University Medical Center Utrecht and Amsterdam UMC Nephrology and Hypertension Utrecht Netherlands -
Joris I. Rotmans j.i.rotmans@lumc.nl Leiden University Medical Center Internal Medicine Leide Netherlands -
Alferso C. Abrahams A.C.Abrahams@umcutrecht.nl University Medical Center Utrecht Nephrology and Hypertension Utrecht Netherlands -
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Vascular access–related complications remain a leading cause of hemodialysis-associated morbidity. However, limited evidence are available on vascular access outcomes in home hemodialysis (HHD) patients. 

This cohort study, part of the Dutch nOcturnal and hoME dialysis Study To Improve Clinical Outcomes (DOMESTICO), included adult HHD patients (≥18 years) between April 1, 2018, and August 31, 2023, using either arteriovenous fistulas (AVFs) or central venous catheters (CVCs) as their primary hemodialysis access. The primary outcome was a composite event of vascular access–related complications requiring interventions, defined as the first occurrence of any of the following: percutaneous transluminal angioplasty, shunt surgery, catheter exchange, or infection-requiring treatment. Survival analysis followed the intention-to-treat approach. Kaplan–Meier curves and multivariable Cox regression was applied.

Among 54 HHD patients (63% AVFs and 37% CVCs), the incidence of composite complications requiring interventions was 18.3 events per 100 patient-year (95% confidence interval [CI]: 9.14-32.75) for AVFs and 12.2 events per 100 patient-years (95%CI: 3.31-31.11). The mean time to first intervention (primary patency) was 2.71 years (95%CI: 2.2-3.22) for AVFs and 3.59 years (95%CI: 2.93-4.25) for CVCs. The rate of infections requiring intervention was 0.07 per 1000 access days (95%CI 0.001-0.025) for AVFs and 0.23 per 1000 catheter days (95%CI: 0.005-0.068) for CVCs.

Among HHD patients, rates of vascular access–related complications requiring interventions, primary patency, and infection were not significantly different between AVF and CVC groups. These findings suggest that CVC maybe a suitable alternatives for patients opt for HHD without AVF.

Kewords