Modified Peritoneal Equilibration Test Analysis in Peritoneal Dialysis Patients

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Modified Peritoneal Equilibration Test Analysis in Peritoneal Dialysis Patients

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Co-author 1

Ikuko Yabana ikuko427@gmail.com Tohoku Medical and Pharmaceutical University Nephrology and Hypertension Sendai Japan *

Co-author 2

Yukari Kikuchi kikuyuka@hosp.tohoku-mpu.ac.jp Tohoku Medical and Pharmaceutical University Integrative Renal Replacement Therapy Sendai Japan -

Co-author 3

Hiroki Ito hito@tohoku-mpu.ac.jp Tohoku Medical and Pharmaceutical University Nephrology and Hypertension Sendai Japan -

Co-author 4

Takefumi Mori tmori@tohoku-mpu.ac.jp Tohoku Medical and Pharmaceutical University Nephrology and Hypertension Sendai Japan -

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Introduction

Modified Peritoneal Equilibration Test (Modified PET) is recommended in the international society of peritoneal dialysis guidelines as a peritoneal function test that can evaluate pure water removal capacity via aquaporin 1, in addition to the peritoneal solute transport capacity and fluid removal capacity assessable by conventional PET.

Methods

Modified PET was performed using 4.25% glucose PD solution in 75 PD patients. Blood tests and effluent tests were conducted at 0, 1, and 4 hours. Due to concerns about abdominal distension, the retention of 4.25% glucose dialysate is set at 1500 mL.

Results

A positive correlation was observed between the sodium dip and the total fluid removal volume, with a significant difference. A sodium dip of ≥5 mmol/L at 1 hour was observed in 58 patients (77.3%), while <5 mmol/L was observed in 17 patients (22.7%). In the group with a sodium dip ≥5 mmol/L, 50 patients (86.2%) had a total fluid removal ≥300 mL, while 8 patients (13.8%) had <300 mL. In the group with a sodium dip <5 mmol/L, 10 patients (58.8%) had total fluid removal ≥300 mL, and 7 patients (41.2%) had <300 mL.

Conclusion

While a positive correlation exists between sodium dip and fluid removal volume, some divergent cases were observed, suggesting that comprehensive judgment is necessary for evaluating peritoneal function. However, compared to conventional PET, Modified PET appears to provide more useful information for determining PD menus.

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