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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
We have previously reported at the 67th Annual Meeting of the Japanese Society of Nephrology that chronic water restriction (WR) in rats increases blood pressure and causes significant body mass loss to maintain relative body water content per body mass. However, WR also induces a significant decrease in food intake. Therefore, it is not clear whether the physiological response to WR, such as blood pressure elevation and body mass loss, are caused by the water deficit itself or by the concurrent caloric restriction. Therefore, this study aimed to dissociate the specific effects of water deficit versus reduced food intake using a pair-feeding (PF) model in rats.
Male 8 weeks old Sprague-Dawley（SD）were divided into three groups: 1) control (ad libitum food and water), 2) water restriction (WR, 30% restriction of water intake), and 3) pair-feeding (PF, ad libitum water but food intake matched to the WR group). Blood pressure (telemetry), water and food intake, and body weight changes were monitored for 7 days. At the end of the study, body wet weight, water, dry weight and relative body water content (ml/g dry weight) were also evaluated.
Compared with the control group, the WR group exhibited a significant increase in blood pressure. This effect was completely absent in the PF group, which maintained normal blood pressure like the control group, indicating that the blood pressure elevation is a direct consequence of water deficit, not caloric restriction. In contrast, both the WR and PF groups showed a significant and comparable reduction in body weight compared with the control group. Also, WR and PF comparably decreased body wet weight, water and dry weight, as a result, relative body water content was maintained in both groups compared with the control group. This indicates that the associated reduction in food intake primarily drives the body mass loss observed during WR.
These findings suggest that distinct mechanisms drive the physiological responses to water restriction, such as blood pressure elevation and body mass loss. The increase in blood pressure is specifically associated with water deficit, independent of food intake. The body mass loss is primarily a consequence of the accompanying reduction in food intake and not water deficit. This reduction in body mass may serve as an adaptive response to water scarcity, compensating to maintain relative tissue hydration (ml/g ratio) by reducing the total body dry mass.
