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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Chronic kidney disease of unknown etiology (CKDu) is highly prevalent in Latin America. Aguascalientes, Mexico, has emerged as one of the regions with the highest prevalence, associated with prenatal oligonephronia, glomerulomegaly, and adaptive focal segmental glomerulosclerosis (FSGS) in adolescents and young adults. Recent studies have reported the presence of silica in renal tissue from CKDu patients in Central America, and experimental evidence has demonstrated silica-induced toxicity through oxidative stress and mitochondrial dysfunction in cellular models.
Objective: To evaluate the presence of silica in renal biopsy specimens from adolescents with adaptive podocytopathy and adults with adaptive FSGS from the Aguascalientes region, Mexico, using single-particle inductively coupled plasma mass spectrometry (SP-ICP-MS). In addition, potential environmental exposure sources were explored through silica quantification in local water systems.
Methods: A case-control study including four groups: Group 1: Adolescents with adaptive podocytopathy (n = 10). Group 2: Adults with adaptive FSGS (n = 20). Group 3: Adults with glomerulopathy other than FSGS (n = 12). Group 4: Control group (renal tissue from trauma nephrectomies, n = 10).
Results: A total of 52 individuals were included (median age 30 years, IQR 18–42); 50.9% (n = 27) were female. Silica particles were detected in a higher proportion among adolescents and adults with adaptive FSGS (66% and 65[JB1] %, respectively) compared with the other two groups (0% and 10%, p < 0.01).Silica was detected in water from non-commercial purification plants, whereas no silica was detected in the public water system (72,272.8 vs. 0 silica particles/ml, p < 0.001).
Group 1
Adolescents
(n=10)
Group 2
Adults FSGS
(n=20)
Group 3
Other GMN
(n=12)
Group 4
Adult Control
In the population of Aguascalientes, Mexico, the presence of silica in renal tissue was significantly more frequent among adolescents and adults with adaptive podocytopathy or FSGS than in control individuals, suggesting a potential environmental contribution to CKDu pathogenesis in this hotspot region.
