Back
For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".
To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".
During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Peritoneal dialysis (PD) is an important kidney replacement therapy for children with end-stage kidney disease (ESKD). Children require greater ultrafiltration (UF) per body surface area than adults. To maintain a stable fluid balance throughout the day, net UF during the long, daytime dwell is particularly crucial for anuric patients. In adults, icodextrin dialysate (ICO) achieved greater UF than 2.5% glucose dialysate (2.5% GD) during long dwells.
However, its efficacy in pediatric PD remains unclear. This study aimed to determine whether ICO would be able achieve better UF and solute clearance than 2.5% GD during long (12-hour) and intermediate (8-hour) dwell exchanges in children undergoing PD.
The present, multicenter, randomized crossover trial enrolled pediatric PD patients aged < 18 years who had been undergoing PD for at least three months. Patients with peritonitis or abdominal surgery within three months prior to study commencement were excluded. Participants were randomly assigned to two sequences: Group A (ICO→2.5% GD) and Group B (2.5% GD→ICO). Each dialysate was tested for two consecutive days using standard dwell volumes of 800 ± 100 mL/m² for 8-hour and 12-hour exchanges.
The primary outcome was the difference in UF volume per body surface area between ICO and 2.5% GD during the 12-hour dwell. Secondary outcomes included the difference in UF by peritoneal transport category and during the 8-hour dwell and solute removal performance (urea nitrogen, creatinine, potassium, phosphate).
Twenty-four of 25 participants completed the study (males: 13; median age: 4.0 years, median PD duration: 22.0 months, anuric patients: 13). Peritoneal equilibration test (PET) categories were high (H) in eight, high-average (HA) in 12, and low-average (LA) in four, patients.
During the 12-hour dwell, ICO achieved significantly greater UF than 2.5% GD (mean difference: 136.9 mL/m²; 95% CI: 75.6–198.2; p<0.01). The superiority of ICO was evident in the H and HA groups (172.2 and 155.9 mL/m², respectively; both p<0.01) but not in the LA group (17.8 mL/m²; p=0.72). For the 8-hour dwell, UF did not differ significantly between ICO and 2.5% GD (15.8 mL/m²; 95% CI: −25.0–56.6; p=0.43). Solute removal (urea nitrogen, creatinine, potassium, phosphate) was significantly higher with ICO during the 12-hour dwell (all p<0.05). One case of Grade 3 hyponatremia occurred but was deemed unrelated to ICO, and no serious adverse events were observed.
In pediatric PD, ICO demonstrated superior UF and solute removal than 2.5% GD during a 12-hour long-dwell exchange, particularly in patients with high peritoneal transport characteristics. ICO may therefore help optimize long-dwell PD performance in children with ESKD.
