PREEMPTIVE KIDNEY TRANSPLANTATION: 10-YEAR PATIENT AND GRAFT SURVIVAL

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PREEMPTIVE KIDNEY TRANSPLANTATION: 10-YEAR PATIENT AND GRAFT SURVIVAL

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Co-author 1

David Garcia Ramirez dr.garcia.nefro@gmail.com Mexican Social Security Institute Nephrology Mexico City Mexico *

Co-author 2

Ariana Maria Martinez Sanchez dra.ariana.martinez.nefro@gmail.com Mexican Social Security Institute Nephrology Mexico City Mexico -

Co-author 3

José Fernando Real Garcia fernando.real@uabc.edu.mx Mexican Social Security Institute Nephrology Mexicali Mexico -

Co-author 4

Ricardo Ibarra Valenzuela dr.ricardoibarra.nefro@gmail.com Mexican Social Security Institute Nephrology Hermosillo Mexico -

Co-author 5

Julio David Rios Ramirez Julio.rios93@outlook.com Mexican Social Security Institute Nephrology Mexicali Mexico -

Co-author 6

Abraham Edgar Gracia Ramos dr.gracia.dmm@gmail.com La Raza ,National Medical Center, Mexican Social Security Institute Internal Medicine Mexico City Mexico -

Co-author 7

Luis Enrique Alvarez Rangel Luis.enrique.alvarez.rangel@hotmail.com La Raza ,National Medical Center, Mexican Social Security Institute Nephrology Mexico City Mexico -

Co-author 8

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Co-author 10

Co-author 11

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Introduction

Preemptive kidney transplantation can help avoid costs and morbidity associated with dialysis. However, clinical benefits of PKT, have not yet been conclusively demonstrated. The objective of our study was to compare 10-year patient and graft survival between recipients of Preemptive kidney transplantation and recipients of kidney transplantation after the start of dialysis ( Preemptive kidney transplantation) .

Methods

Retrospective study of the records of recipients of kidney transplants from living donors. Patients were divided into two groups: 1) Preemptive kidney transplantation (PKT) and 2) non-preemptive kidney transplantation (nPKT). Patient and graft survival at 10 years was analyzed using the Kaplan-Meier method, comparing the differences between groups using the log-rank test. A p-value <0.05 was considered significant.

Results

A total of 1,048 clinical records of kidney transplant recipients were reviewed (921 [87.9%] from living donors and 127 [12.1%] from deceased donors). Only living donor recipients aged 27.82 ± 9.36 years were included. Among them, 71 cases (7.7%) were identified with preemptive kidney transplantation (PKT) and 850 (92.3%) with kidney transplantation after the start of dialysis (nPKT). Ten-year patient survival was 97.2% in the PKT group and 91.1% in the nPKT group, p=0.080. Graft survival was 93.0% in the PKT gropu and 83.8% in the nPKT group, p=0.047.

Conclusion

Among recipients of kidney transplants from living donors, patient survival rates were comparable between those who underwent preemptive kidney transplantation and Non-preemptive kidney transplantation. However, graft survival was higher in the preemptive kidney transplantation group. It is necessary to continue with the registry in order to corroborate the clinical benefits in long-term graft survival and, based on this, to be able to increase the number of preemptive kidney transplants.

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