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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
It has long been hypothesized that heterogeneous activation of the renin–angiotensin system (RAS) within individual nephrons contributes to the development of hypertension. However, the underlying mechanisms leading to intrarenal RAS activation remain unclear. We hypothesized that luminal narrowing of afferent arterioles in chronic kidney disease (CKD) is involved in the upregulation of intrarenal RAS. The present study investigated whether renal arteriolar remodeling is associated with urinary angiotensinogen (UAGT), a marker of intrarenal RAS activity.
Among 172 patients who underwent renal biopsy at our institution between 2010 and 2013, 54 patients were included after excluding those with fewer than 10 evaluable arterioles or taking RAS inhibitors. IgA nephropathy was the most common underlying disease (57.4%). Arteriolar remodeling was evaluated by measuring the wall-to-lumen ratio (WLR), calculated as (outer diameter − inner diameter)/inner diameter. In addition to conventional risk factors, high-sensitivity C-reactive protein (hs-CRP), oxidative stress marker (dROM), flow-mediated vasodilation (%FMD), and UAGT were assessed. Correlations between WLR and these variables were analyzed. Multivariate regression analysis was used to determine the association of UAGT with WLR adjusted with conventional risk factors and estimate glomerular filtration rate (eGFR).
The mean age and eGFR were 38 years and 81 mL/min/1.73 m², respectively. Log-transformed UAGT levels were positively correlated with Log WLR, LDL cholesterol, and Log dROM, and negatively correlated with eGFR. In multivariate regression analysis, Log WLR remained significantly associated with Log UAGT (β = 0.38, p = 0.04), independent of conventional risk factors and eGFR .
These findings suggest that renal arteriolar remodeling is associated with intrarenal RAS activation in patients with CKD. Structural changes in afferent arterioles may play an important role in the pathophysiology linking microvascular injury and intrarenal RAS activation.
