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E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
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Abstract titles should be brief and reflect the content of the abstract.
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare autoimmune disorder characterized by the coexistence of uveitis and tubulointerstitial nephritis. It has been reported TINU syndrome is more frequently in children than in adults but immunological features of TINU syndrome has not been well defined. We aimed to investigate the immunological characteristics of pediatric TINU syndrome cases at our institution.
We retrospectively analyzed patients under 18 years of age diagnosed with definite TINU syndrome at Kyushu University Hospital from 2017 to 2025. Definite diagnosis was made on the presence of uveitis and histological diagnosis of acute interstitial nephritis which often accompanies with elevated serum creatinine and increased urinary tubular injury markers such as β2-microglobulin. Children with asymptomatic hematuria detected by school urinary screeningwere evaluated as controls. We analyzed clinical features, laboratory findings at onset, peripheral blood lymphocyte and monocyte subsets, and serum cytokine profiles. In the TINU group, these immunological parameters were also assessed before and after treatment.
The TINU and control groups consisted of five patients each. There were no significant differences in sex ratio, age at diagnosis, height, or weight. Serum creatinine, serum IgG, and urinary β2-microglobulin levels at onset were significantly higher in the TINU group. Soluble IL-2 receptor levels were elevated in the TINU group (median 949.5 U/mL, range 544–1586), exceeding the normal range (156–474.3 U/mL). Flow cytometric analysis revealed a significantly higher proportion of B cells in the TINU group than in controls (23.27% vs. 15.7%, p = 0.0122) and a lower proportion of T cells (57.95% vs. 73.43%, p = 0.0367). Moreover, T cells in the TINU group expressed more HLA-DR on the surface than in controls. The proportion of inflammatory (CD14⁺CD16⁺) monocytes was also significantly increased (8.06% vs. 3.25%, p = 0.0367). No significant differences were observed in serum cytokine levels between the groups. In the TINU group, the proportion of B cells decreased significantly (24.2% vs. 15.2%, p = 0.0289) after treatment, whereas no significant changes were observed in monocyte subsets or serum cytokines.
TINU syndrome was reported to involve the production of autoantibody and immune mechanisms mediated by CD4⁺ T cells and B cells, leading to uveitis and nephritis. In this study we found inflammatory monocytes, activated T cells and increased B cells population as well as higher soluble IL-2 receptor level in peripheral blood of the TINU group, which may reflect these underlying immunopathological processes in pediatric TINU syndrome.
