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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Pregnancy in chronic kidney disease (CKD) is associated with risks of obstetric and fetal complications. Proper pre-conception counselling for women with progressive CKD of different primary causes and supportive care with close monitoring during pregnancy for those with stable kidney disease are essential measures to ensure a safe pregnancy in chronic kidney disease. To date, literature regarding pregnancy outcome in CKD is scarce with no data in Malaysia.
This is a single-center, retrospective observational cohort study, involving all pregnancies in patients with CKD from 1stJanuary 2014 to 31st December 2023 in a tertiary center. We aimed to determine the prevalence of CKD progression, successful pregnancy, obstetric and fetal complications, and their associative factors.
166 patients were recruited, with a median (IQR) age of 31.0 (6.0) years. Majority of them were Malay (84.3%), with normal body mass index (83.1%). Lupus nephritis (34.3%) and IgA nephropathy (30.1%) were the predominant primary kidney diseases, with 80.7% stage 1 CKD and 85.5% baseline proteinuria of more than 300 mg per day. 18.7% patients had progression of CKD after the pregnancy, with gestational diabetes mellitus as the only independent preventive factor (OR 0.00, p = 0.046) (Table 1).
75.3% of pregnancies were successful, which were affected by the baseline proteinuria of more than 300 mg per day (OR 0.12, p = 0.049) and gestational diabetes mellitus (OR 16.24, p = 0.008) (Table 2).
There were 46.4% obstetric complications, majority of which were gestational diabetes mellitus (20.5%), gestational hypertension (20.5%), and pre-eclampsia (18.1%); and 46.4% fetal complications, mainly miscarriage (15.1%) and premature birth (19.3%). Overweight and obesity were the only independent risk factor for the development of obstetric complications in CKD with a normal body mass index OR of 0.25 (p <0.001) (Table 3). There was no independent risk factor identified for the development of fetal complication using multivariate analysis.
Pregnancy is feasible in women with CKD when managed with close monitoring and multidisciplinary care. In our cohort, three-quarters of pregnancies resulted in successful outcomes, although obstetric and fetal complications remained common. Baseline proteinuria and gestational diabetes mellitus significantly influenced pregnancy success, with gestational diabetes mellitus showing a paradoxical association as both a frequent complication and a predictor of favorable outcomes. Progression of CKD occurred in nearly one-fifth of patients, highlighting the need for vigilant post-partum follow-up. Overweight and obesity emerged as key modifiable risk factors for obstetric complications. These findings emphasize the importance of pre-conception counselling, optimization of proteinuria and body weight, and tailored antenatal care to improve maternal and fetal outcomes in CKD pregnancies.
