Global Awareness and Information-Seeking Behavior in Polycystic Kidney Disease: A 21-Year Google Trends Infodemiology Study (2004–2025)

 

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Global Awareness and Information-Seeking Behavior in Polycystic Kidney Disease: A 21-Year Google Trends Infodemiology Study (2004–2025)

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Benjamin
Bizer
Benjamin Bizer bizer.benjamin@mayo.edu Mayo Clinic Nephrology and Hypertension Rochester United States *
Jose Arriola-Montenegro arriolamontenegro.jose@mayo.edu Mayo Clinic Nephrology and Hypertension Rochester United States -
Charat Thongprayoon thongprayoon.charat@mayo.edu Mayo Clinic Nephrology and Hypertension Rochester United States -
Iasmina Craici craici.iasmina@mayo.edu Mayo Clinic Nephrology and Hypertension Rochester United States -
Wisit Cheungpasitporn cheungpasitporn.wisit@mayo.edu Mayo Clinic Nephrology and Hypertension Rochester United States -
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Polycystic kidney disease (PKD), encompassing autosomal dominant (ADPKD) and autosomal recessive (ARPKD) forms, is a prevalent inherited disorder affecting over 10 million individuals worldwide. Despite its high disease burden and significant economic impact, which is estimated to exceed $7 billion annually in the United States, public awareness and information-seeking behavior surrounding PKD remain poorly characterized. Quantifying global public interest can reveal disparities in disease awareness and inform targeted education, advocacy, and policy initiatives.

We conducted a 21-year infodemiology analysis using Google Trends to assess worldwide search activity for the term “polycystic kidney disease” between January 2004 and October 2025. Relative search volume (RSV; range 0–100) was normalized by population to allow cross-country comparison. Temporal and geographic patterns were analyzed, including peak, trough, and seasonal fluctuations. Comparative analyses were performed against related queries (“ADPKD,” “autosomal dominant PKD”) to evaluate evolving trends in disease-specific awareness.

Global public interest in PKD remained relatively stable between 2004 and 2025. After an early peak in the mid-2000s, interest declined with mild annual variation. A dip occurred during the COVID-19 pandemic (index: 46), followed by a gradual recovery. Seasonal lows were observed in December, January, June, and July, with the highest annual interest recorded in 2004. Trinidad & Tobago and Ethiopia (index: 100) had the highest relative search interest, followed by Ghana (95) and Jamaica (91). Between 2023 and 2024, the largest increases were seen in Trinidad & Tobago (+90), Ethiopia (+52), and Palestine (+41), while Myanmar (−26), Kyrgyzstan (−31), and Zambia (−17) showed the greatest declines.

Compared to "ADPKD" and "autosomal dominant PKD," both of which trended upward since 2004, "PKD" had consistently higher overall interest.


Comparison of Search Interest between Different Polycystic Kidney Diseases Worldwide 2004-2025



Public awareness of PKD has remained steady over two decades but varies substantially across regions. The identification of high-engagement and low-awareness areas underscores opportunities for global nephrology societies and advocacy groups to implement data-driven educational campaigns. Monitoring search behavior may serve as a valuable tool to inform public health strategies and improve global awareness of polycystic kidney disease.

Kewords