EVALUATING THE IMPACT OF TIDAL VOLUMEN IN AUTOMATED PERITONEAL DIALYSIS ON THE MANAGEMENT OF HYPERPHOSPHATEMIA

 

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EVALUATING THE IMPACT OF TIDAL VOLUMEN IN AUTOMATED PERITONEAL DIALYSIS ON THE MANAGEMENT OF HYPERPHOSPHATEMIA

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Stefany
Jacob Kuttothara
Stefany Jacob Kuttothara skuttothara@gmail.com Instituto Nacional de Cardiologia Nephrology Department Mexico City Mexico *
Karla Berenice Cano Escobar k.berenicecano@gmail.com Instituto Nacional de Cardiologia Nephrology Department Mexico City Mexico -
Gabriela Leal Escobar leal.gabriela@hotmail.com Instituto Nacional de Cardiologia Nephrology Department Mexico City Mexico -
Luis Daniel Ramirez Calvillo daniel.ramirez.cal@gmail.com Instituto Nacional de Cardiologia Nephrology Department Mexico City Mexico -
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Hyperphosphatemia is a frecuent and clinically significant complication in peritoneal dialysis (PD), associated with mineral bone disorders and increased cardiovascular risk. It is more prevalent in individuals on automated peritoneal dialysis (APD) than on continuous ambulatory peritoneal dialysis (CAPD).  Tidal peritoneal dialysis (TPD) may offer a theoretical  advantage in the management of hyperphosphatemia;  however, its application in this context remains largely underexplored.

A quasi-experimental, pre-post study was conducted at a single center between March and August 2025.  44 APD patients were transitioned to TPD for 6 weeks. Serum phosphorus (primary outcome), PTH, calcium, hemoglobin, BUN, creatinine, and ultrafiltration were analyzed. Statistical analysis was performed using  paired or independent t tests and Wilcoxon tests as appropriate.

The mean age was 47.2 ± 15.8 years,  59% being female, mean duration on PD was 46.8 ± 35.2 months. Phosphorus levels were significantly reduced from 6.16 ± 1.44 to 5.35 ± 0.94 mg/dL (p < 0.001) following TPD.  A phosphorus reduction was obsered in 81.8% of patients, with  40.9% achieving a decrease ≥1.0 mg/dL.  A more profound effect was observed in patients with hyperphosphatemia (>5.5mg/dL), experiencing a mean reduction of -1.20 mg/dL, compared to those without hyperphosphatemia that remained relatively stable, with a slight increase of +0.23 mg/dL (p < 0.05.  PTH levels also decreased significantly from 344.0 ± 221.3 to 312.2 ± 211.5 pg/mL (p<0.05), other parameters remained unchanged. TPD modality was well tolerated by all patients

Variable

Basal (Mean±SD o Median [IC])

Tidal (Mean±SD o Median [IC])

p value

Phosphorus (mg/dL)

6.16 ± 1.44

5.35 ± 0.94

< 0.001

PTH  (pg/ml)

344.02 ± 221.34

312.20 ± 211.47

< 0.05

Calcium (mg/dL)

9.24 (8.50-10.00)

9.38 (8.85-9.70)

0.476

Hemoglobin (g/dL)

10.05 (9.00-11.93)

10.10 (9.10-11.95)

0.375

BUN (mg/dL)

58.99 ± 12.16

59.63 ± 11.89

0.740

Creatinine (mg/dL)

13.41 ± 3.88

13.27 ± 3.69

0.595

Total ultrafiltration (ml)

914.00 (458.75-1231.75)

928.00 (476.25-1314.25)

0.561

Albumin (mg/dL)

3.96 ± 0.48

3.89 ± 0.44

0.286

Potassium (mg/dL)

4.60 (4.25-5.00)

4.71 (4.11-5.12)

0.578

Phosphorus intake (mg in 24 horas)

1240.78 ± 503.64

1209.09 ± 418.33

0.606

Total Volume (L)

9.35 (7.55-11.57)

9.60 (7.47-11.85)

0.172


TPD is often recommended for patients who experience discomfort or prolonged drainage times, this study highlighs additional potential clinical benefits.  The effect was more pronounced in patients with baseline hyperphosphatemia supporting TPD as a viable adjunctive strategy in the management of hyperhphosatemia in APD

Kewords