THE EFFECT OF PHYSICAL ACTIVITY ON INTRADIALYTIC VASCULAR DYSFUNCTION

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THE EFFECT OF PHYSICAL ACTIVITY ON INTRADIALYTIC VASCULAR DYSFUNCTION

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Co-author 1

Maksud Sabirov nefrologiya2019@mail.ru Republican Specialized Scientific and Practical Medical Center of Nephrology and Kidney Transplantation Administration Tashkent Uzbekistan -

Co-author 2

Olimkhon Sharapov olimkhon@gmail.com Republican Specialized Scientific and Practical Medical Center of Nephrology and Kidney Transplantation Adult and Pediatric Nephrology Tashkent Uzbekistan -

Co-author 3

Bakhodir Nigmonov dr.nigmonov@gmail.com Tashkent State Medical University Internal diseases, nephrology and hemodialysis Tashkent Uzbekistan -

Co-author 4

Aziz Daminov dr.nefrology@gmail.com Tashkent State Medical University Internal diseases, nephrology and hemodialysis Tashkent Uzbekistan *

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Introduction

The aim of the study was to investigate the intradialytic dynamics of endothelium-dependent vasodilation (EDVD) during intradialytic exercise.

Methods

This study included 103 patients with end-stage renal disease (ESRD) and 20 healthy age-matched volunteers. All study participants underwent instrumental examination, including endothelial function testing (brachial artery EDVD test). Data obtained in the patient group (103 individuals) were compared with data obtained in the healthy volunteer group (20 individuals).

Results

Patients with ESRD, compared with healthy individuals, demonstrated impaired endothelial function, confirmed by a decreased degree of EDVD (9.23±0.24% vs. 12.90±0.25%, p<0.001, statistically significant). Hemodialysis (HD) is associated with a further deterioration in endothelial vasoactive function (a decrease in EDVA to 2.64%) by the 60th to 90th minute. By the end of HD, endothelial dysfunction continues to worsen progressively, with EDVA decreasing to 0.88%.

Conclusion

Intradialytic endothelial dysfunction is more pronounced in individuals under 41 years of age compared to older individuals. Intradialytic physical exercise has a protective effect on the progression of endothelial dysfunction by the 60th to 90th minute of dialysis: trends toward normalization of endothelium-dependent vasodilation are observed by the end of the hemodialysis session.

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