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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Kidney transplantation outcomes are strongly influenced by immunological compatibility between donor and recipient. While genetic mismatches in the Human Leucocyte Antigen (HLA) region have long been recognized as key determinants of graft survival, increasing evidence, including our own previous work, suggests that non-HLA alloimmunity also plays a critical role.
We sequenced the exomes of 1187 pairs of deceased kidney donors and recipients from a prospective cohort at the Vienna General Hospital recruited between January 1, 2012, and June 15, 2023. Non-HLA mismatch was computed by considering non-synonymous single nucleotide polymorphisms encoding for proteins in the kidney that are transmembrane proteins located in the cell membrane or secreted (nsSNP-tcmsk). Using adjusted Cox proportional hazards models, we replicated results from our earlier work in recipients with primary graft function after 90 days, and extended the analysis to the combination of nsSNP-tcmsk with Eplets mismatch to assess their associations with graft loss in the full cohort.
Of 20421 human proteins, 2371 were considered for the nsSNP-tcmsk score. In our replication analysis we estimated a hazard ratio (HR) for nsSNP-tcmsk of 1.33 (95% CI 1.02-1.74) for graft loss per increase of one interquartile range. The nsSNP-tcmsk and Eplets scores were uncorrelated ( 0.04). A composite score of nsSNP-tcmsk and Eplets mismatches was associated with graft loss with a HR of 1.76 (95% CI 1.20-2.57) corresponding to an absolute difference in 7-year restricted mean survival time between the 1st and 4th quartiles of 0.52 years (95% CI 0.16-0.87 years).
The impact of non-HLA donor-recipient mismatch on transplant loss is of the same magnitude as established mismatch scores in the HLA region. Together, these compatibility scores may be further validated as guiding markers for the required strength of maintenance immunosuppression.
